A Monoclonal Antibody against Prothrombin Fragment 1 Behaves Like a Lupus Anticoagulant

• References

• 1 Galli M, Finazzi G, Bevers EM, Barbui T. Kaolin clotting time and dilute Russells viper venom time distinguish between prothrombin-dependent and beta-2-glycoprotein I dependent antiphospholipid antibodies. Blood 1995; 86: 617-23.
• 2 Takeya H, Mori T, Gabazza EC. et al Anti beta-2-glycoprotein I (beta2GPI) monoclonal antiborlies with Iupus anticoagulant activity enhance the beta2GPI binding to phospholipids. J Clin Invest 1997; 99: 2260-8.
• 3 Arnout J, Vanrusselt M, Wittevrongel C, Vermylen J. Monoclonal anti-badies against beta-2 glycoprotein 1: Use as reference material for Iupus anticoagulant tests. Thromb Haemost 1998; 79: 955-8.
• 4 Arvieux J, Darnige L, Caron C. et al Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with Iupus anticoagulants. Thromb Haemost 1995; 74: 1120-5.
• 5 Malia RG, Brookfield C, Bulman L, Greaves M. Prothrombinfragment Fl.2; The epitope for antiphospholipid antibody expression (abstract). Thromb Haemost. 1997 78/2: 170(0C-689).
• 6 Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of Iupus anticoagulants: An update. Thromb Haemost 1995; 74: 1185-90.