Coexistence of Factor V Leiden and Factor II A20210 Mutations and Recurrent Venous Thromboembolism

Maurizio Margaglione; Giovanna D’Andrea; Donatella Colaizzo; Giuseppe Cappucci; Annamaria del Popolo; Vincenzo Brancaccio; Antonio Ciampa; Elvira Grandone; Giovanni Di Minno

doi:10.1055/s-0037-1614882

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(06): 1583-1587
DOI: 10.1055/s-0037-1614882

Rapid Communication

Schattauer GmbH

Coexistence of Factor V Leiden and Factor II A20210 Mutations and Recurrent Venous Thromboembolism

Authors

Maurizio Margaglione

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Giovanna D’Andrea

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Donatella Colaizzo

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Giuseppe Cappucci

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Annamaria del Popolo

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Vincenzo Brancaccio

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Antonio Ciampa

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Elvira Grandone

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
Giovanni Di Minno

¹From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Divisione di Ematologia, Ospedale “G. Moscati”, Avellino, and Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy

Abstract

Summary

Patients carrying the FV Leiden or the FII A²⁰²¹⁰ mutation have a high risk of venous thromboembolism. Among 542 patients with a documented diagnosis of deep venous thrombosis in one leg consecutively referred for a thrombophilic work-up, we have retrospectively assessed the rate of objectively documented previous recurrence in carriers of both FV Leiden and FII A²⁰²¹⁰ mutations. Eighty-two patients had experienced 115 episodes of recurrent venous thromboembolism. The rate of recurrent venous thromboembolism was 29.2% among subjects with and 14.5% in those without deficiencies of natural anticoagulant proteins (p = 0.055), and 24.6% among patients with and 14.0% in those without antiphospholipid antibodies (p = 0.036). The frequency of having a recurrent thromboembolism was 16.2%, 20.0%, and 36.4% among carriers of FV Leiden, FII A²⁰²¹⁰ mutation, or both gene defects, respectively, and 12.8% in subjects carrying neither mutation (p for trend = 0.004). When adjusted for age, sex, and thrombophilic risk factors, the rate was higher among patients with than in those without deficiencies of natural anticoagulant proteins (OR: 3.0; 95% CI: 1.2-7.5), aPL 2.5 (95% CI: 1.3-4.9), or both FV Leiden and FII A²⁰²¹⁰ gene mutations (OR 4.8; 95% CI: 1.9-12.2).

The rate of previous recurrent venous thromboembolism was significantly higher in subjects carrying both FV Leiden and FII ²⁰²¹⁰ mutations and was comparable to that observed in subjects with deficiencies of natural anticoagulant proteins or antiphospholipid antibodies.

Key Words

FV Leiden - FII A²⁰²¹⁰ - thrombosis - veins - risk factors

Full Text

References

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