Effect of Antihypertensive Treatment with Doxazosin on Insulin Sensitivity and Fibrinolytic Parameters

Manfred Zehetgruber; Günter Christ; Harald Gabriel; Gerald Mundigler; Renate Beckmann; Bernd R. Binder; Kurt Huber

doi:10.1055/s-0037-1614995

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(02): 378-382
DOI: 10.1055/s-0037-1614995

Letters to the Editor

Schattauer GmbH

Effect of Antihypertensive Treatment with Doxazosin on Insulin Sensitivity and Fibrinolytic Parameters

Authors

Manfred Zehetgruber
Günter Christ
Harald Gabriel
Gerald Mundigler
Renate Beckmann

²Vascular Biology and Thrombosis Research, University of Vienna, Austria
Bernd R. Binder

²Vascular Biology and Thrombosis Research, University of Vienna, Austria
Kurt Huber

Abstract

Summary

The effects of the selective alpha-1-adrenoceptor antagonist doxazosin on metabolic and fibrinolytic parameters were studied in hypertensive patients with various degrees of fasting plasma insulin levels (Group A: 22.5 ± 3 μU/ml, Group B: 8.1 ± 1.5 μU/ml; p <0.01) to disclose a potential link between a doxazosin-induced alteration of insulin and/or lipid metabolism and possible changes of these parameters on the fibrinolytic system. Doxazosin treatment resulted in a dose-dependent reduction of basal insulin levels in group A to 16 ± 3 μU/ml; p <0.05. This finding was paralleled by a dose-dependent increase in t-PA_mass concentration in the same patient group (basal t-PA_mass from 9.7 ± 1 to 15.5 ± 2 ng/ml; p <0.05). As PAI-1 “active” as well as total antigen levels were not altered in parallel, the net effect on the endogenous fibrinolytic system is an increase of the fibrinolytic potential.

Full Text

References

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