Thromb Haemost 1998; 80(02): 239-241
DOI: 10.1055/s-0037-1615180
Rapid Communication
Schattauer GmbH

Superficial Vein Thrombosis of Lower Limbs: Influence of Factor V Leiden, Factor II G20210A and Overweight

Philippe de Moerloose
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
,
Robert Wutschert
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
,
Monica Heinzmann
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
,
Thomas Perneger
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
,
Guido Reber
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
,
Henri Bounameaux
1  Division d’Angiologie et d’Hémostase, Hôpital Universitaire Genève, Genève, Switzerland and Institut de Médecine Sociale et Préventive, Université de Genève, Switzerland
› Author Affiliations
Further Information

Publication History

Received 16 February 1998

Accepted after resubmission 21 April 1998

Publication Date:
08 December 2017 (online)

Summary

Superficial vein thrombosis (SVT) has been reported in patients with thrombophilia. In the present unmatched case-control study, the two most common thrombophilic abnormalities (factor V Leiden and factor II G20210A) were searched for in 112 consecutive patients with SVT of lower limbs and in 180 healthy donors. FV Leiden was present in 16/112 (14.3%) SVT patients and 11/180 (6.1%) controls (odds ratio 2.51, 95% CI 1.04-6.24) and FII G20210A in 4/112 (3.6%) patients and 2/180 (1.1%) controls (OR 3.28, 95% CI 0.46-36.84). In addition, body mass index (BMI) ≥28 kg/m2 was also associated with SVT (OR 2.81, 95% CI 1.60-5.00). After adjustement for BMI ≥28 kg/m2, the association between FV Leiden and SVT remained strong though no longer statistically significant. Among patients with SVT, the presence of FV Leiden was independently associated with the absence of varicose veins (OR 4.62, 95% CI 1.25-18.0) and with a BMI ≥28 kg/m2 (OR 3.74, 95% CI 1.05-15.1). In conclusion, both FV Leiden and overweight seem to predispose to SVT, a finding that should be confirmed in larger studies.