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Thromb Haemost 1998; 80(03): 388-392
DOI: 10.1055/s-0037-1615217
Rapid Communications
Schattauer GmbH

Effect of Cilostazol on Soluble Adhesion Molecules and Platelet-derived Microparticles in Patients with Diabetes[*]

Shosaku Nomura
1   From the First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Akira Shouzu
2   From the Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Seitaro Omoto
2   From the Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Takashi Hayakawa
2   From the Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Hideo Kagawa
1   From the First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Mitsushige Nishikawa
2   From the Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Mitsuo Inada
2   From the Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Yoshihiro Fujimura
3   From the Department of Blood Transfusion, Nara Medical College, Kashihara, Japan
,
Yasuo Ikeda
4   From the Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Shirou Fukuhara
1   From the First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
› Author Affiliations
Further Information

Publication History

Received 06 March 1998

Accepted 13 May 1998

Publication Date:
08 December 2017 (online)

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Summary

We evaluated the plasma concentrations of soluble adhesion molecules and platelet-derived microparticles (PMP) in patients with non-insulin dependent diabetes mellitus (NIDDM) and studied the effect of cilostazol on PMP generation. There were differences in the levels of soluble adhesion molecules between NIDDM patients (N = 43) and the control subjects (N = 30) (soluble thrombomodulin: 11.5 ± 5.3 vs. 7.0 ± 1.2 TU/ml, p<0.0001; soluble vascular cell adhesion molecule-1: 708 ± 203 vs. 492 ± 113 ng/dl, p<0.0001; soluble intercellular cell adhesion molecules-1: 274 ± 65 vs. 206 ± 48 ng/dl, p<0.0001; soluble P-selectin: 194 ± 85 vs. 125 ± 43 ng/dl, p<0.0001). There were also differences in the levels of PMP and platelet activation markers between NIDDM patients and the controls (PMP: 943 ± 504 vs. 488 ± 219/10 4 plt, p<0.0001; platelet CD62P: 9.2 ± 4.6 vs. 4.4 ± 4.3%, p<0.001; platelet CD63: 10.2 ± 4.5 vs. 4.5 ± 3.3%, p<0.0001; platelet annexin V: 9.1 ± 3.9 vs. 5.3 ± 3.8%, p<0.001). To study the release of PMP into plasma, a modified cone-and-plate viscometer was used. Increased release of PMP from platelets was observed in diabetic plasma compared to normal plasma under high shear stress conditions (2,672 ± 645 vs. 1,498 ± 386/104 plt, p<0.05). Therefore, one cause of PMP elevation in NIDDM may be high shear stress. The levels of PMP, activated platelets, and soluble adhesion molecules all decreased significantly after treatment with cilostazol. These results suggest that cilostazol may be useful for the inhibition of both PMP-dependent and -independent vascular damage in NIDDM.

* Grant support: This work was partly supported by a Research Grant for Advanced Medical Care from the Ministry of Health and Welfare of Japan.


 

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