Induction of Endothelial Cell Adhesion Molecules by Serum and Immunoglobulins G from a Patient with Vasculitis and Monoclonal Gammapathy: Potential Relevance to Vasculitis

Evelyne Dupuy; Jean-Marc Herbert; Véronique Giraudeau; Isabelle Quere; Jean-Marc Zini; Gérard Tobelem

doi:10.1055/s-0037-1615232

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1998; 80(03): 477-480
DOI: 10.1055/s-0037-1615232

Rapid Communications

Schattauer GmbH

Induction of Endothelial Cell Adhesion Molecules by Serum and Immunoglobulins G from a Patient with Vasculitis and Monoclonal Gammapathy: Potential Relevance to Vasculitis

Authors

Evelyne Dupuy

¹From the Department of Hematology
Jean-Marc Herbert

³From the Sanofi Recherche, Toulouse, France
Véronique Giraudeau

²From the Laboratory of Biochemistry, Hôpital Lariboisière, Paris
Isabelle Quere

¹From the Department of Hematology
Jean-Marc Zini

¹From the Department of Hematology
Gérard Tobelem

¹From the Department of Hematology

Abstract

Summary

Interactions between endothelial cell adhesion molecules and their β₂ integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G₂ kappa (IgG₂K). During the vasculitic crisis, the patient’s serum and the isolated IgG from this serum induced the expression of E-selectin, VCAM-1 and ICAM-1 at the HUVEC surface, but not tissue factor activity, whereas normal, control serum and patient serum at remission were without any effect.

A close relationship between the vasculitis and the serum level of the monoclonal IgG was observed. We suggest that the monoclonal IgG might induce the vasculitis by increasing the expression of E-selectin, VCAM-1 and ICAM-1 which facilitate the interaction of leukocytes with vascular endothelium.

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Referenzen

References
1 Fauci AS, Haynes BF, Katz P. The spectrum of vasculitis, clinical, pathologic, immunologic and therapeutic considerations. Ann Intern Med 1978; 89: 660-71.
2 Krishnan K, Silveira S. Paraneoplastic cutaneous leucocytoclastic vasculitis in chronic myeloid leukemia: case report and review of the literature. Europ J Haematol 1994; 52: 187-8.
3 Mc Millen JJ, Krueger SK, Dyer GA. Leucocytoclastic vasculitis in association with immunoglobulin A myeloma. Ann Intern Med 1986; 105: 709-10.
4 Morita A, Sakakibara S, Yokota M, Tsuji T. A case of urticarial vasculitis associated with macroglobulinemia (Schnitzler’s syndrome). J Dermatol 1995; 22: 32-5.
5 Thomas FP, Lovelace RE, Ding XS, Sadiq SA, Petty GW, Sherman WH, Latov N, Hays AP. Vasculitic neuropathy in a patient with cryoglobulinemia and anti-MAG IGM monoclonal gammopathy. Muscle & Nerve 1992; 15: 891-8.
6 Asherson RA, Buchanan NM, d’Cruz D, Hughes GR. Urticarial vasculitis, IgA deficiency and C1 esterase inhibitor deficiency in the presence of an IgG monoclonal gammopathy – a case report. Clin Exp Dermatol 1992; 17: 137-9.
7 Yiannias JA, el-Azhary RA, Gibson LE. Erythema elevatum diutinum: a clinical and histopathologic study of 13 patients. J Amer Acad Dermatol 1992; 26: 38-44.
8 Philips MR, Abramson SB, Weissmann G. Neutrophil adhesion and auto-immune vascular injury. Clin Aspects Auto-immun 1989; 3: 6-15.
9 Argenbright LW, Barton RW. Interactions of leukocyte integrins with inter-cellular adhesion molecule 1 in the production of inflammatory injury in vivo. The Shwartzman reaction revisited. J Clin Invest 1992; 89: 259-72.
10 Takeuchi T, Amano K, Sekine H, Abe T. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest 1993; 92: 3008-16.
11 Carlos TM, Harlan JM. Leukocyte – endothelial adhesion molecules. Blood 1994; 84: 2068-101.
12 Laffon A, Garcia-Vicuna R, Humbria A, Postigo A, Corbi A, de Landazuri M, Sanchez-Madrid F. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 1991; 88: 546-52.
13 Suprenant YM, Zuckerman SH. A novel microtiter plate assay for the quantitation of procoagulant activity on adherent monocytes, macrophage and endothelial cells. Thromb Res 1989; 53: 339-42.
14 Del Papa N, Guidali L, Sironi M, Shoenfeld Y, Mantouani A, Tincani A, Balestrieri G, Radice A, Sinico R, Meroni P. Anti-endothelial cell IgG antibodies from patients with Wegener’s granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheumat 1996; 39: 758-66.
15 Tannenbrum SH, Finko R, Cines DB. Antibody and immune complexes induce tissue factor production by endothelial cells. J Immunol 1986; 137: 1532-7.
16 Del Papa N, Guidali L, Spatola L, Bonara P, Borghi M, Tincani A, Balestrieri G, Meroni P. Relationship between anti-phospholipid and anti-endothelial cell antibodies β₂ glycoprotein I mediates the antibody binding to endothelial cells and induces the expression of adhesion molecules. Clin Exp Rhumatol 1995; 13: 179-85.
17 Damianovich M, Gilburg B, George J, Del Papa N, Afek A, Goldberg I, Kopolovic Y, Roth D, Barkai G, Meroni P, Shoenfeld Y. Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model. J Immunol 1996; 156: 4946-51.
18 Gearing AJH, Hemingway J, Pigott R, Hughes J, Rees AJ, Cashman SJ. Soluble forms of vascular adhesion molecules E-selectin, ICAM-1 and VCAM-1: pathological significance. Ann NY Acad Sci 1992; 667: 324-31.
19 Seth R, Raymond FD, Makgoba MW. Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 1991; 338: 83-4.
20 Carson CW, Beall LD, Hunder GG, Johnson CM, Newman W. Serum E-selectin is increased in vasculitis, scleroderma and systemic lupus erythematosus. J Rhumatol 1993; 20: 809-14.
21 Hergesell O, Andrassy F, Nawroth P. Elevated levels of markers of endothelial cell damage and markers of activated coagulation in patients with systemic necrotizing vasculitis. Thromb Haemost 1996; 75: 892-8.