Gorham-Stout Disease Management during Pregnancy

Elena Bargagli; Caterina Piccioli; Edoardo Cavigli; Marianna Scola; Elisabetta Rosi; Federico Lavorini; Luca Novelli; Dario Ugolini; Tommaso Notaristefano; Pieralli Filippo; Vittorio Miele; Camilla E. Comin; Massimo Pistolesi; Luca Voltolini

doi:10.1055/s-0037-1615259

American Journal of Perinatology Reports, Table of Contents

CC-BY-NC-ND 4.0 · AJP Rep 2017; 07(04): e226-e229
DOI: 10.1055/s-0037-1615259

Case Report

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Gorham-Stout Disease Management during Pregnancy

Authors

Elena Bargagli

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Caterina Piccioli

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Edoardo Cavigli

²Department of Radiodiagnostic and Emergency, Careggi University Hospital, Florence, Italy
Marianna Scola

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Elisabetta Rosi

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Federico Lavorini

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Luca Novelli

³Department of Pathology, Careggi University Hospital, Florence, Italy
Dario Ugolini

⁴Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy
Tommaso Notaristefano

⁴Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy
Pieralli Filippo

⁵Subintentive Medicine Section, Careggi University Hospital, Florence, Italy
Vittorio Miele

²Department of Radiodiagnostic and Emergency, Careggi University Hospital, Florence, Italy
Camilla E. Comin

³Department of Pathology, Careggi University Hospital, Florence, Italy
Massimo Pistolesi

¹Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
Luca Voltolini

⁴Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy

Abstract

Gorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. Chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. Extrapulmonary alterations may include chylous ascites, lymphopenia, and destructing bone disease for overgrowth of lymphatic vessels. Here, we report the case of a young woman who developed a severe and recalcitrant GSD with persistent unilateral chylothorax during pregnancy. The complex management of this patient during and after pregnancy was discussed and compared with literature data to contribute to the definition of a correct diagnostic and therapeutic approach to this rare lymphatic disease.

Keywords

gorham-stout disease - pregnancy - lung - treatment

Full Text

References

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