FVIII Coagulant Activity and Antigen in Subjects with Ischaemic Heart Disease

Gillian I. Rice; Peter J. Grant

doi:10.1055/s-0037-1615354

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(05): 757-762
DOI: 10.1055/s-0037-1615354

Review Article

Schattauer GmbH

FVIII Coagulant Activity and Antigen in Subjects with Ischaemic Heart Disease

Authors

Gillian I. Rice

¹From the Unit of Molecular Vascular Medicine, Division of Medicine, School of Medicine, University of Leeds, UK
Peter J. Grant

¹From the Unit of Molecular Vascular Medicine, Division of Medicine, School of Medicine, University of Leeds, UK

Abstract

Summary

Raised factor VIII coagulant activity has been associated with Ischaemic Heart Disease and Myocardial Infarction (MI). We measured FVIII:C and FVIII:Ag levels in 288 white European patients characterised for extent of atheroma by coronary angiography and for a history of MI by WHO criteria, and 313 white European healthy controls. FVIII:Ag levels were higher in patients than controls after adjustment for confounding variables (1.17 IU/ml patients, 1.03 IU/ml controls [p <0.0005]), whereas FVIII:C levels were lower in patients (1.26 IU/ml patients, 1.45 IU/ml controls [p < 0.0005]). FVIII:Ag levels were higher in patients with MI and with angiographic evidence of atheroma than controls. FVIII:Ag levels but not FVIII:C levels were a significant independent risk factor for MI in multivariate analysis (Odds Ratio 2.40 [1.35-4.27] [p = 0.003]). No association of FVIII:Ag or FVIII:C levels and presence or extent of atheroma was found in multivariate analysis. In conclusion, this study found an independent association of FVIII:Ag but not FVIII:C with MI.

Full Text

References

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