Economic Impact of the Introduction of the ProC® Global Assay in the Screening Strategy of Protein C Pathway Abnormalities in Unselected Patients with a History of Venous Thromboembolism

References
1 Kraus M, Noah M, Fickenscher K. The PCAT – a simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res 1995; 79: 217-22.
2 Toulon P, Halbmeyer WM, Hafner G, Schmitt Y, Randgard B, Odpadlik M, Van Den Eynden C, Wagner C. Screening for abnormalities of the protein C anticoagulant pathway using the ProC Global assay. Results of a European multicenter trial. Blood Coag Fibrinol 2000; 11: 447-54.
3 Zotz RB, Gerhardt A, Scharf RE. ProC^® Global assay is an independent predictor for venous thromboembolism. Blood 1998; 92 Suppl.1 44a. [abstract]
4 Rosendaal FR, van den Meer FJM, Visser Th, Wagner C. ProC^® Global screening test and the risk of thrombosis. Thromb Haemost 1999; 82 Suppl 731. [abstract]
5 Dati F, Hafner G, Erbes H, Prellwitz W, Kraus M, Niemann F, Noah M, Wagner C. ProC^® Global: the first functional screening assay for the complete protein C pathway. Clin Chem 1997; 43: 1719-23.
6 Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlbäck B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia. Part 1. Thromb Haemost 1996; 76: 651-62.
7 Kraus M. The anticoagulant potential of the protein C system in hereditary and acquired thrombophilia: pathomechanisms and new tools for assessing its clinical relevance. Semin Thromb Hemost 1998; 24: 337-54.
8 Ruzicka K, Kapiotis S, Quehenberger P, Handler S, Pabinger-Fasching I, Mannhalter C, Jilma B, Speiser W. Evaluation of a new screening assay ProC^® Global for identification of defects in the protein C/protein S anticoagulant pathway. Thromb Res 1997; 87: 501-10.
9 Tripodi A, Akhavan S, Asti D, Faioni EM, Mannucci PM. Laboratory screening of thrombophilia. Evaluation of the diagnostic efficacy of a global test to detect congenital deficiencies of the protein C anticoagulant pathway. Blood Coag Fibrinol 1998; 9: 485-9.
10 Gemmati D, Serino ML, Scapoli GL. A modified functional global test to measure protein C, protein S activities and the activated protein C-resistance phenotype. Thromb Res 1998; 92: 141-8.
11 Toulon P, Perez P, Demay Y, Dornon O, Adda R. ProC Global, a new assay to evaluate the functionality of the protein C anticoagulant pathway. Preliminary results in 223 consecutive patients with a history of venous thromboembolism. Fibrinolysis Proteolysis 1998; 12: 347-52.
12 Rosén S, Johansson K, Lindberg B, Dahlbäck B. Multicenter evaluation of a kit for activated protein C resistance on various coagulation instruments using plasmas from healthy individuals. Thromb Haemost 1994; 72: 255-60.