The use of recombinant factor VIIa in a patient with essential thrombocythaemia with uncontrolled surgical bleeding

• References

• 1 Barbui T, Finazzi G. Management of essential thrombocythemia.. Crit Rev Oncol Hematol 1999; 29: 257-66.
• 2 el Kassar N, Hetet G, Li Y. et al Clonal analysis of haemopoietic cells in essential thrombocythaemia.. Br J Haematol 1995; 90: 131-7.
• 3 Fialkow PJ, Faguet GB, Jacobson RJ. et al Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell.. Blood 1981; 58: 916-9.
• 4 Lisman T, Adelmeijer J, Heijnen HF. et al Recombinant factor VIIa restores aggregation of alphaIIbbeta3- deficient platelets via tissue factor independent fibrin generation.. Blood 2004; 103: 1720-7.
• 5 Lisman T, Moschatsis S, Adelmeijer J. et al Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor-independent thrombin generation.. Blood 2003; 101: 1864-70.
• 6 Peters M, Heijboer H. Treatment of a patient with Bernard-Soulier syndrome and recurrent nosebleeds with recombinant factor VIIa.. Thromb Haemost 1998; 80: 352
• 7 Poon MC, Demers C, Jobin F. et al Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia.. Blood 1999; 94: 3951-3.
• 8 Revesz T, Arets B, Bierings M. et al Recombinant factor VIIa in severe uremic bleeding.. Thromb Haemost 1998; 80: 353
• 9 Roberts HR. Recombinant factor VIIa: a general hemostatic agent? Yes.. J Thromb Haemost 2004; 2: 1691-4.
• 10 van Genderen PJ, Budde U, Michiels JJ. et al The reduction of large von Willebrand factor multimers in plasma in essential thrombocythaemia is related to the platelet count.. Br J Haematol 1996; 93: 962-5.