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J Neurol Surg B Skull Base 2018; 79(01): 058-064
DOI: 10.1055/s-0037-1617450
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Rhabdomyosarcoma of the Head and Neck: A Multimodal Approach

Dana L. Casey
1   Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States
,
Suzanne L. Wolden
1   Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States
› Author Affiliations
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Publication History

Publication Date:
18 January 2018 (online)

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Abstract

Head and neck rhabdomyosarcoma (HNRMS) is a uniquely challenging site to treat given the young patient age and critical anatomy of the head and neck region. We review the characteristics, management, and future directions in the treatment of HNRMS. Most patients who present with HNRMS have unresectable disease due to functional and/or cosmetic constraints. However, surgical resection and brachytherapy serve a critical role in select patients. The treatment paradigm for the majority of patients with HNRMS consists of definitive chemotherapy and radiation therapy. As the incidence of late toxicities increases with improved survival, modern efforts must focus on ways to decrease long-term morbidity. We recommend a multimodal approach emphasizing the preservation of form and function for the treatment of HNRMS.

Keywords

pediatric rhabdomyosarcoma - head and neck neoplasms - radiotherapy - brachytherapy