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Hamostaseologie 2000; 20(04): 201-204
DOI: 10.1055/s-0037-1619493
Original article
Schattauer GmbH

Wirkung von Thrombininhibitoren auf ein humanes, experimentelles Thrombosemodell zur Vermeidung von Tierversuchen

Effect of thrombin inhibitors in a human experimental thrombosis model to avoid animal experiments
J. Harenberg
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
,
K. Zokai
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
,
L. Piazolo
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
,
T. Fenyvesy
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
,
U. Hoffmann
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
,
G. Huhle
1   I. Medizinische Klinik, Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim
› Author Affiliations
Further Information

Publication History

Publication Date:
22 December 2017 (online)

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Zusammenfassung

Die Entwicklungen neuer Antithrombotika mit Wirkung auf das Gerinnungssystem oder die Rezeptoren der Thrombozyten stellen einen wichtigen Schwerpunkt in der medizinischen Forschung dar. Im Rahmen dieser Entwicklungsprojekte sind die Ergebnisse zur Wirksamkeit in Thrombosemodellen am Tier von entscheidender Bedeutung. Ihre Übertragbarkeit auf den Menschen wird jedoch kritisch beurteilt. In einem Ex-vivo-Thrombosemodell mit humanem Vollblut wurden daher zunächst die Dosisabhängigkeit von Thrombininhibitoren geprüft, um die Aussagefähigkeit des Modells zu belegen.

Summary

The development of new antithrombotic drugs on the blood coagulation system and on receptors of platelets represents an important area of medical research. The results of the efficacy in animal models are of critical importance for the further development to man. The transferability of such data from animal to human species still remains critical. The antithrombotic effects of direct thrombin inhibitors were investigated in an ex vivo thrombosis model with human blood in order to analyse the feasibility of such model.

Schlüsselwörter

Thrombosemodell - Antithrombotika - Thrombininhibitoren - Blutgerinnung - Thrombozyten

Keywords

Thrombosis model - antithrombotic drugs - thrombin inhibitors - blood coagulation - platelets
 

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