Zytostatische Chemotherapie: Einflüsse auf das Hämostasesystem

Zusammenfassung

Gerinnungsstörungen bei bösartigen Erkrankungen sind durch vielfältige Wechselwirkungen zwischen Tumorzellen, deren Produkten und dem Organismus bedingt. Diese führen zu einer verschieden stark ausgeprägten Beeinträchtigung der Hämostase und können dadurch Thromboembolien oder Blutungen verursachen. Die zugrundeliegenden Mechanismen der Einflussnahme von Zytostatika auf das Gerinnungssystem werden beschrieben. Die Daten zur prophylaktischen Antikoagulation während Chemotherapie sind widersprüchlich.

Summary

Coagulation disorders in malignancies are due to complex interactions between tumor cells, their products and the organism leading to various degrees of impairment of haemostasis. This can cause either thromboembolism or bleeding. The risk of such complications increases during chemotherapy. The underlying mechanisms influencing the haemostatic system influenced by cytostatic agents are described. Data supporting the use of prophylactic anticoagulation in patients with malignancy and during chemotherapy are inconsistent.

Schlüsselwörter

Hämostase - Zytostatische Chemotherapie

Keywords

Haemostasis - cytostatic chemotherapy

• Literatur

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