Wirkung von Bisphophonaten auf Osteoporoseschmerzen

Zusammenfassung

Die analgetische Wirkung der Bisphosphonate in der Onkologie wurde vielfach nachgewiesen. Bei Nichttumorschmerzen ist deren schmerzstillende Wirkung weniger gut dokumentiert. Zwar gibt es eine Vielzahl tierexperimenteller Daten zur analgetischen Wirkung von Bisphosphonaten, aber nur in einer einzigen placebokontrollierten Studie konnte eine mäßige analgetische Wirkung von Pamidronat nachgewiesen werden. Auf der anderen Seite können Bisphosphonate bei der Erstgabe von Langzeitpräparaten Schmerzen und grippeähnliche Symptome auslösen; dieser Effekt kann durch eine adäquate Vorbehandlung der Patienten verhindert werden.

Summary

The analgesic effect of bisphosphonates in malignant tumours is well known. In non-malignant pain there is a variety of experimental data showing an analgesic effect of bisphosphonates. Clinical data are rare; in a single placebo controlled trial a moderate analgesic effect of pamidronate has been shown. On the other side bisphosphonates can cause pain and flue-like symptoms when administered for the first time; preventive measures for this effect should be taken.

Schlüsselwörter

Osteoporose - Bisphosphonate - Schmerz

Keywords

Osteoporosis - bisphosphonates - pain

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