Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1978; 17(06): 266-269
DOI: 10.1055/s-0037-1620705

Originalarbeiten – Original Articles

Schattauer GmbH

Microautoradiographic Studies on the Cellular Localization of Radiothallium^[*]

Mikroautoradiographische Untersuchungen der zellulären Verteilung von Radiothallium

P. Som

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

K. Matsui

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

H.L. Atkins

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

E. Lebowtiz

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

D.D. Greenberg

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

A.N. Ansari

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

J.F. Klopper

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

D.F. Sacker

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

,

L.F. Hathorn

¹From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA

› Author Affiliations

²⁰¹Tl-chloride and ²⁰⁴Tl-nitr-ate were similarly distributed in organs of mice 10 min and 60 min after intravenous injection. Autoradiographic studies were carried out with ²⁰⁴Tl-nitrate in rats (injected intraperitoneally) as well as in mice and dogs (injected intravenously). Thallium localized in the cells of proximal and distal convoluted tubules and collecting tubules of the kidney. In the intestines, it was distributed mostly in the cells of the smooth musculature and surface epithelium of the villi. Some silver grains were seen in the goblet cells and in the lumen as well. It localized in the sarcoplasm of the myocardium and the skeletal muscle cells. In thyroid, most of the thallium was seen in the colloidal part of the follicle. In testes, silver grains were seen in and around the cells of Sertoli and in the lumen of the seminiferous tubules. Some localized concentration in the interstitial cells of the testes was also observed.

Die Organverteilung von ²⁰¹Tl-chlorid und ²⁰⁴T1-Nitrat wurde 10 und 60 Min. nach intravenöser Injektion bei Mäusen untersucht. Die Organverteilung der beiden Thalliumisotope war ähnlich. Autoradiographische Untersuchungen wurden mit ²⁰⁴T1 an Ratten (intraperitoneale Injektion) sowie Hunden und Mäusen (intravenöse Injektion) durchgeführt. Thallium fand sich in Zellen der proximalen und distalen Nierentubuli sowie in den Sammelröhrchen der Nieren. Im Darm war das Isotop hauptsächlich in den glatten Muskelzellen und im Zottenepithel zu finden. Gelegentliche Silberkörnchen kamen auch in Becherzellen sowie im Darmlumen vor. Herzmuskelzellen und Skeletmuskelzellen enthielten Thallium. In der Schilddrüse wurde das Isotop besonders im Follikelinhalt angereichert gefunden. In den Testes wurden Silberkörnchen in und um die Sertolischen Zellen und im Lumen der Tubuli seminiferi gesehen. Auch die interstitiellen Zellen der Testes zeigten gelegentliche Ansammlungen von Thallium.

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