Download PDF
Nuklearmedizin 1981; 20(02): 82-84
DOI: 10.1055/s-0037-1620721
Originalarbeiten – Original Articles
Schattauer GmbH

Response of Adrenal Catecholamine to a Newly Synthesized Chemical Radioprotector

Reaktion des Nebennieren-Katecholamins auf eine neuentwickelte Strahlenschutzverbindung
S. S. Hasan
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
S. Mazumdar
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
P.M. Singh
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
S.N. Pandey
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
› Author Affiliations
Further Information

Publication History

Received 02 February 1981

Publication Date:
10 January 2018 (online)

  PDF Download  Permissions and Reprints

This study was undertaken to try a newly synthesized compound (1-acetyl hydrazinyl thiophenyl formamidine dihydro-chloride) as a chemical radioprotector and to observe its effects on adrenal catecholamine and protein bound iodine (PBI). After whole-body irradiation, the catecholamine and serum PBI levels decreased significantly but treatment with the drug before irradiation increased the same. The whole-body irradiation resulted in a 50% mortality within a fortnight whereas the use of the drug prevented it.

Diese Untersuchung wurde unternommen, um eine neu synthetisierte Verbindung (1-Azetyl Hydrazinyl Thiophenyl Formamidin Dihydrochlorid) als strahlenschützende Substanz zu prüfen und ihren Effekt auf Nebennierenrinden-Katecholamin und das eiweißgebundene Jod (PBI) zu beobachten. Nach einer Ganzkörperbestrahlung sanken die Katecholamin- und Serum-PBI-Spiegel signifikant, während die Verabreichung der Verbindung vor der Bestrahlung sie dagegen erhöhte. Die Ganzkörperbestrahlung bewirkte eine 50%ige Mortalität innerhalb von zwei Wochen, während die Verwendung dieser Verbindung dies verhinderte.

 

  • References

  • 1 Acland J. D. The estimation of serum protein bound iodine by alkaline incineration. Biochem. J 1957; 66: 177.
    CrossrefPubMedGoogle Scholar
  • 2 Bonefi F, Nuvolone V. Efficacia radioprotettiva di derivad cisteamines. Latina 1958; 1: 162.
    Google Scholar
  • 3 Crout J. R, Creveling D. R, Udenfriend S. Norepinephrine metabolism in the rat brain and heart. J. Pharmacol. exp. Ther 1961; 132: 269.
    PubMedGoogle Scholar
  • 4 Foye W. O, Mickel J. Antiradiation compounds. II. Dithiocarbamates. J. med. Pharm. Chem 1962; 5: 846.
    CrossrefPubMedGoogle Scholar
  • 5 Hasan S. S, Sarkar F. H, Sharma T. R, Prasad G. C, Pant G. C, Udupa K. N. Response of adrenal gland to whole body Co60 irradiation. Ind. J. exp. Biol 1977; 15: 513-516.
    Google Scholar
  • 6 Hasan S. S, Sarkar F. H, Pandey S. N, Udupa K. N. A note on the response of adrenal gland and its catecholamine to chemical radioprotector. Ind. J. Anim 1978; 48: 698-700.
    Google Scholar
  • 7 Hasan S. S, Sarkar F. H, Singh P. M, Mazumdar S, Prasad G. C, Pant G. C, Udupa K. N. Response of brain bioamines and its enzymes to Cobald-60 irradiation. Strahlenther 1978; 154: 349-354.
    Google Scholar
  • 8 Pihl A, Eldjarn L. Pharmacological aspects of ionizing radiation and of chemical protection in mammals. Pharm. Rev 1958; 10: 437-474.
    PubMedGoogle Scholar
  • 9 Prasad G. C, Hasan S. S, Pandey S. N, Mazumdar S, Singh P. M. Biogenic amine. Response to whole body irradiation. Prevention by APTH. Acta radiol. One 1978; 17: 510-516.
    Google Scholar