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Nuklearmedizin 1981; 20(02): 82-84
DOI: 10.1055/s-0037-1620721
Originalarbeiten – Original Articles
Schattauer GmbH

Response of Adrenal Catecholamine to a Newly Synthesized Chemical Radioprotector

Reaktion des Nebennieren-Katecholamins auf eine neuentwickelte Strahlenschutzverbindung

Authors

  • S. S. Hasan

    1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India

  • S. Mazumdar

    1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India

  • P.M. Singh

    1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India

  • S.N. Pandey

    1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
Further Information

Publication History

Received 02 February 1981

Publication Date:
10 January 2018 (online)

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This study was undertaken to try a newly synthesized compound (1-acetyl hydrazinyl thiophenyl formamidine dihydro-chloride) as a chemical radioprotector and to observe its effects on adrenal catecholamine and protein bound iodine (PBI). After whole-body irradiation, the catecholamine and serum PBI levels decreased significantly but treatment with the drug before irradiation increased the same. The whole-body irradiation resulted in a 50% mortality within a fortnight whereas the use of the drug prevented it.

Diese Untersuchung wurde unternommen, um eine neu synthetisierte Verbindung (1-Azetyl Hydrazinyl Thiophenyl Formamidin Dihydrochlorid) als strahlenschützende Substanz zu prüfen und ihren Effekt auf Nebennierenrinden-Katecholamin und das eiweißgebundene Jod (PBI) zu beobachten. Nach einer Ganzkörperbestrahlung sanken die Katecholamin- und Serum-PBI-Spiegel signifikant, während die Verabreichung der Verbindung vor der Bestrahlung sie dagegen erhöhte. Die Ganzkörperbestrahlung bewirkte eine 50%ige Mortalität innerhalb von zwei Wochen, während die Verwendung dieser Verbindung dies verhinderte.