Tierarztl Prax Ausg K Kleintiere Heimtiere 2010; 38(S 01): S41-S44
DOI: 10.1055/s-0038-1622884
Ausgewählter Kongressbeitrag
Schattauer GmbH

Immunmodulation bei atopischer Dermatitis – Wunschdenken oder Wissenschaft?

R. S. Müller
1   Medizinische Kleintierklinik (Leitung: Prof. Dr. K. Hartmann) der Ludwig-Maximilians-Universität München
› Author Affiliations
Further Information

Publication History

Publication Date:
05 January 2018 (online)


  • Literatur

  • 1 Stedman’s Medical Dictionary. Philadelphia: Lippincott Williams & Wilkins; 2000: 882
  • 2 Akdis M. Immune tolerance in allergy. Curr Opin Immunol. 2009. (E-Publikation vor dem Druck)
  • 3 Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007; 119: 780-791.
  • 4 Bashir ME, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C. An enteric helminth infection protects against an allergic response to dietary antigen. J Immunol 2002; 169: 3284-3292.
  • 5 Bernstein JA, Kagen SL, Bernstein DI, Bernstein IL. Rapid venom immuno-therapy is safe for routine use in the treatment of patients with Hymenoptera anaphylaxis. Ann Allergy 1994; 73: 423-428.
  • 6 Carvalho EM, Bastos LS, Araujo MI. Worms and allergy. Parasite Immunology 2006; 28: 525-534.
  • 7 Cooper PJ, Chico ME, Rodrigues LC. et al Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol 2003; 111: 995-1000.
  • 8 Creticos PS, Schroeder JT, Hamilton RG. et al Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006; 355: 1445-1455.
  • 9 Gleich GJ, Zimmermann EM, Henderson LL, Yunginger JW. Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study. J Allergy Clin Immunol 1982; 70: 261-271.
  • 10 Graham SP, Trees AJ, Collins RA. et al Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis. Infect Immun 2001; 69: 4313-4319.
  • 11 Harvey RG. Management of feline miliary dermatitis by supplementing the diet with essential fatty acids. Vet Rec 1991; 128: 326-329.
  • 12 Helmer M, Epe C, Mueller RS. The effect of helminth administration on canine atopic dermatitis – a pilot study. Vet Dermatol 2008; 19: 34
  • 13 Hites MJ, Kleinbeck ML, Loker JL, Lee KW. Effect of immunotherapy on the serum concentrations of allergen-specific IgG antibodies in dog sera. Vet Immunol Immunopathol 1989; 22: 39-51.
  • 14 Hurst MH, Lola SG, Lindberg R. Immunomodulation of the hepatic egg granuloma in Schistosoma japonicum-infected pigs. Parasite Immunol 2006; 28: 681-686.
  • 15 Keppel KE, Campbell KL, Zuckermann FA, Greeley EA, Schaeffer DJ, Hus-mann RJ. Quantitation of canine regulatory T cell populations, serum inter-leukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immuno-therapy. Vet Immunol Immunopathol 2008; 123: 337-344.
  • 16 Loewenstein C, Mueller RS. A review of allergen-specific immunotherapy in human and veterinary medicine. Vet Dermatol 2009; 20: 84-98.
  • 17 Marshall JD, Abtahi S, Eiden JJ. et al Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy. J Allergy Clin Immunol 2001; 108: 191-197.
  • 18 Medeiros Jr. M, Figueiredo JP, Almeida MC. et al Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol 2003; 111: 947-951.
  • 19 Mueller RS, Bettenay SV. Long-term immunotherapy of 146 dogs with atopic dermatitis – a retrospective study. Aust Vet Pract 1996; 26: 128-132.
  • 20 Mueller RS, Bettenay SV, Tan W. Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Am J Vet Res 2001; 62: 307-311.
  • 21 Mueller RS, Fieseler KV, Fettman MJ. et al Effect of omega-3 fatty acids on canine atopic dermatitis. J Small Anim Pract 2004; 45: 293-297.
  • 22 Mueller RS, Fieseler KV, Zabel S, Rosychuk RAW. Conventional and rush immunotherapy in canine atopic dermatitis. In Advances in Veterinary. Dermatology V, Hillier A, Foster AP, Kwochka KW. eds Oxford: Blackwell; 2005: 60-69.
  • 23 Mueller RS, Veir J, Fieseler KV, Dow SW. Use of immunostimulatory lipo-some-nucleic acid complexes in allergen-specific immunotherapy of dogs with refractory atopic dermatitis – a pilot study. Vet Dermatol 2005; 16: 61-68.
  • 24 Noon L. Prophylactic inoculation against hay fever. Lancet 1911; 1: 1055-1057.
  • 25 Nuttall T, Mueller R, Bensignor E. et al Efficacy of a 0.0584% hydrocortisone aceponate spray in the management of canine atopic dermatitis: a randomised, double blind, placebo-controlled trial. Vet Dermatol 2009; 20: 191-198.
  • 26 Nuttall TJ, Thoday KL, van den Broek AH, Jackson HA, Sture GH, Halliwell RE. Retrospective survey of allergen immunotherapy in canine atopy. Vet Rec 1998; 143: 139-142.
  • 27 Olivry T, Marsella R, Iwasaki T, Mueller R. Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol 2007; 18: 78-86.
  • 28 Olivry T, Mueller RS. Evidence-based veterinary dermatology: A systematic review on the pharmacotherapy of canine atopic dermatitis. Vet Dermatol 2003; 14: 121-146.
  • 29 Olivry T, Steffan J, Fisch RD. et al Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs. J Am Vet Med Assoc 2002; 221: 370-377.
  • 30 Patterson R, Harris KE. Rush immunotherapy in a dog with severe ragweed and grass pollen allergy. Ann Allergy Asthma Immunol 1999; 83: 213-216.
  • 31 Rosser EJ. Aqueous hyposensitization in the treatment of canine atopic dermatitis: a retrospective study of 100 cases. In Advances in Veterinary Dermatology. Kwochka KW, Willemse T, von Tscharner C. eds Oxford: Butter-worth-Heinemann; 1996: 128-132.
  • 32 Saevik BK, Bergvall K, Holm BR. et al A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. Vet Dermatol 2004; 15: 137-145.
  • 33 Schnabl B, Bettenay SV, Dow K, Mueller RS. Results of allergen-specific immunotherapy in 117 dogs with atopic dermatitis. Vet Rec 2006; 158: 81-85.
  • 34 Scott KV, White SD, Rosychuk RAW. A retrospective study of hyposensitization in atopic dogs in a flea-scarce environment. In Advances in Veterinary Dermatology. Ihrke PJ, Mason IS, White SD. eds New York: Pergamon Press; 1993: 79-87.
  • 35 Steffan J, Alexander D, Brovedani F, Fisch RD. Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial. Vet Dermatol 2003; 14: 11-22.
  • 36 Steffan J, Favrot C, Mueller R. A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet Dermatol 2006; 17: 3-16.
  • 37 Stehle ME, Goebel T, Hancaruk M, Mueller RS. The influence of polyunsatu-rated fatty acids on the T cell response in dogs with atopic dermatitis. Proceedings of the 22th North American Veterinary Dermatology Forum, Lihue, Kauai 2007; 194
  • 38 Thelen A, Mueller RS, Linek M, Peters S, Stechmann K, Steffan J. Influence of food intake on the clinical response to cyclosporin A in canine atopic dermatitis. Vet Rec 2006; 159: 854-856.
  • 39 Vaughn DM, Reinhart GA, Swaim FS. et al Evaluation of effects of dietary n-6 to n-3 fatty acid ratios on leukotriene B synthesis in dog skin and neutrophils. Vet Dermatol 1994; 5: 163-173.
  • 40 Wallace FA, Miles EA, Evans C, Stock TE, Yaqoob P, Calder PC. Dietary fatty acids influence the production of Th1– but not Th2-type cytokines. J Leukoc Biol 2001; 69: 449-457.
  • 41 Willemse A, Van den Brom WE, Rijnberk A. Effect of hyposensitisation on atopic dermatitis in dogs. J Am Vet Med Assoc 1984; 184: 1277-1280.
  • 42 Zur G, White SD, Ihrke PJ, Kass PH, Toebe N. Canine atopic dermatitis: a retrospective study of 169 cases examined at the University of California, Davis, 1992–1998. Part II. Response to hyposensitization. Vet Dermatol 2002; 13: 103-111.