Tierarztl Prax Ausg K Kleintiere Heimtiere 2014; 42(01): 55-59
DOI: 10.1055/s-0038-1623739
Case Report
Schattauer GmbH

Feline osteochondromatosis in a FELV-negative European shorthair cat

Feline Osteochondromatose bei einer FELV-negativen Europäisch-KurzhaarKatze
M. C. Nolff
1   Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany
2   Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximillians-University, Munich, Germany
,
C. Puff
3   Department of Pathology, University of Veterinary Medicine Hanover, Foundation, Hanover, Germany
,
B. Länger
1   Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany
,
M. Fehr
1   Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany
› Author Affiliations
Further Information

Publication History

Received: 21 September 2012

Accepted after revision: 26 February 2013

Publication Date:
07 January 2018 (online)

Summary

Objective: To report palliative treatment in a case of multifocal feline osteochondromatosis in a feline leukaemia virus (FeLV) negative European shorthair cat. Case: A 6-year-old spayed female European shorthair cat was presented because of a right forelimb lameness caused by an osteochondromatous lesion which had trapped tendons, vessels and nerves of the antebrachium. Several other lesions were present which did not cause the animal discomfort. The cat was tested negative for FeLV. Palliative surgical removal of the mass was performed, resulting in a marked improvement of mobility with no local recurrence. The cat developed a non-regenerative anaemia after surgery, however the underlying cause was not identified upon request of the owner. Overall survival after surgery was only 2 months. The cat was then euthanised due to severe progression of the anaemia. Conclusion: Palliative surgical removal of osteochondromas may result in local improvement. However, owners need to be aware that it does not increase overall survival and that the prognosis is poor. Infection with FeLV is not necessarily associated with such lesions.

Zusammenfassung

Gegenstand: Beschrieben wird ein Fall multifokaler feliner Osteochondromatose bei einer FELV-negativen Europäisch-Kurzhaar-Katze. Fall: Die 6-jährige kastrierte Katze wurde mit einer deutlichen Lahmheit der rechten Vordergliedmaße vorgestellt. Ursache war eine osteochondromatöse Zubildung am Antebrachium, die Sehnen, Nerven und Gefäße einbezogen hatte. An verschiedenen anderen Lokalisationen fanden sich weitere derartige Zubildungen, die dem Tier jedoch keine Probleme bereiteten. Eine FeLV-Infektion wurde weder im Serum noch in der Läsion festgestellt. Durch die palliative chirurgische Resektion der Neubildung am Unterarm bildete sich die Lahmheitssymptomatik vollständig zurück. Postoperativ entwickelte die Katze eine aregenerative Anämie, deren ursächliche Abklärung der Besitzer verweigerte. Zwei Monate nach der Operation musste das Tier aufgrund der Anämie euthanasiert werden. In dieser Zeit kam es zu keinem lokalen Rezidiv oder einer erneuten Lahmheit. Schlussfolgerung: Eine palliative Entfernung osteochondromatöser Zubildungen kann klinische Symptome verbessern, doch bleibt die Prognose bei multifokalen Läsionen vorsichtig. Eine FeLV-Infektion ist bei betroffenen Tieren nicht immer nachweisbar.

 
  • References

  • 1 Alexander JW. Selected skeletal dysplasias: craniomandibular osteopathy, multiple cartilaginous exostoses, and hypertrophic osteodystrophy. Vet Clin North Am Small Anim Pract 1983; 13: 55-70.
  • 2 Brown RJ, Trevethan WP, Henry VL. Multiple osteochondroma in a Siamese cat. J Am Vet Med Assoc 1972; 160: 433-435.
  • 3 Carpenter JL, Andrews LK, Holzworth J. Tumors and tumor-like lesions. In Diseases of the Cat: Medicine and Surgery. Holzworth J. ed. Philadelphia: Saunders; 1987: 407-596.
  • 4 Carrig CB. Growth abnormalities of the canine radius and ulna. Vet Clin North Am Small Anim Pract 1983; 13: 91-115.
  • 5 Chandler EA, Gaskell RM, Gaskell CJ. Feline Medicine & Therapeutics. 3rd edn.. Oxford: Blackwell; 2004
  • 6 Cullen J. Viral carcinogenesis. In: Tumors in Domestic Animals. 4th edn.. Meuten D. ed. Iowa: Iowa State Press; 2002: 16-20.
  • 7 Darilek S, Wicklund C, Novy D. et al. Hereditary multiple exostosis and pain. J Pediatr Orthop 2005; 25: 369-376.
  • 8 Essex M, Cotter SM, Carpenter JL. Feline virus-induced tumors and the immune response: recent developments. Am J Vet Res 1973; 34: 809-812.
  • 9 Franch J, Font J, Ramis A. et al. Multiple cartilaginous exostosis in a Golden Retriever cross-bred puppy. Clinical, radiographic and backscattered scanning microscopy findings. Vet Comp Orthop Traumatol 2005; 18: 189-193.
  • 10 Gradner G. et al. Use of latissimus dorsi and abdominal external oblique muscle for reconstruction of a thoracic wall defect in a cat with feline osteochondromatosis. J Feline Med Surg 2008; 10: 88-94.
  • 11 Green EM, Adams WM, Steinberg H. Malignant transformation of solitary spinal osteochondroma in two mature dogs. Vet Radiol Ultrasound 1999; 40: 634-637.
  • 12 Hameetman L, Szuhai K, Yavas A. et al. The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions. J Natl Cancer Inst 2007; 99: 396-406.
  • 13 Hohdatsu T, Okada S, Ishizuka Y. et al. The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci 1992; 54: 557-562.
  • 14 Jones KB, Piombo V, Searby C. et al. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci USA 2010; 107: 2054-2059.
  • 15 Ligon AH, Potocki L, Shaffer LG. et al. Gene for multiple exostoses (EXT2) maps to 11(p11.2p12) and is deleted in patients with a contiguous gene syndrome. Am J Med Genet 1998; 75: 538-540.
  • 16 Levitin B, Aroch I, Aizenberg I. et al. Linear osteochondromatosis in a cat. Vet Radiol Ultrasound 2003; 44: 660-664.
  • 17 Malik R, Allan GS, Howlett CR. et al. Osteochondrodysplasia in Scottish Fold cats. Aust Vet J 1999; 77: 85-92.
  • 18 Mathews KG. et al. Resolution of lameness associated with Scottish fold osteodystrophy following bilateral ostectomies and pantarsal arthrodeses: a case report. J Am Anim Hosp Assoc 1995; 31: 280-288.
  • 19 Moore AS. Tumors of the skeletal system. In: Feline Oncology. Ogilvie GK, Moore AS. eds. Trenton: Veterinary Learning Systems; 2001: 233-250.
  • 20 Morgan JP, Carlson WD, Adams OR. Hereditary multiple exostosis in the horse. J Am Vet Med Assoc 1962; 140: 1320-1322.
  • 21 Partington BP. et al. What is your diagnosis? Scottish Fold osteodystrophy. J Am Vet Med Assoc 1996; 209: 1235-1236.
  • 22 Pierz KA. et al. Hereditary multiple exostoses: one center’s experience and review of etiology. Clin Orthop Relat Res 2002; 401: 49-59.
  • 23 Pool RR. Osteochondromatosis. In: Disease Mechanism in Small Animal Surgery. 2nd edn.. Bojrab MS. ed. Philadelphia: Lippincott Williams & Wilkins; 1993: 821-833.
  • 24 Reidarson TH, Metz AL, Hardy RM. Thoracic vertebral osteochondroma in a cat. J Am Vet Med Assoc 1988; 192: 1102-1104.
  • 25 Riddle Jr WE, Leighton RL. Osteochondromatosis in a cat. J Am Vet Med Assoc 1970; 156: 1428-1430.
  • 26 Schwab S, Herden C, Seeliger F. et al. Non-suppurative meningoencephalitis of unknown origin in cats and dogs: an immunohistochemical analysis. J Comp Pathol 2007; 136: 96-110.
  • 27 Simon D. Osteochondrodysplasie bei einer Scottish-Fold-Katze. Tierärztl Prax 2000; 28 (K): 86; 107-110.
  • 28 Voss K. Diseases of bone. In: Feline Orthopedic Surgery and Musculosceletal Disease. Montavon PM, Voss K, Langley-Hobbs SJ. eds. Philadelphia: Elsevier Limited; 2009: 60-62.