Preparation and Quality Control of 99mTc-Calciumgluconate

B. Zmbova; D. Djokić; V. Jovanović; I. Tadžer; T. Memedović

doi:10.1055/s-0038-1623797

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1983; 22(03): 166-168
DOI: 10.1055/s-0038-1623797

Originalarbeiten - Original Articles

Schattauer GmbH

Preparation and Quality Control of ^99mTc-Calciumgluconate

Darstellung und Kontrolle der Qualität des ^99mTc-Kalziumglukonats

B. Zmbova

¹From the Boris Kidric Institute of Nuclear Sciences, Vinca, Beograd, University of Skoplje, Yugoslavia

,

D. Djokić

¹From the Boris Kidric Institute of Nuclear Sciences, Vinca, Beograd, University of Skoplje, Yugoslavia

,

V. Jovanović

¹From the Boris Kidric Institute of Nuclear Sciences, Vinca, Beograd, University of Skoplje, Yugoslavia

,

I. Tadžer

^*Institute of Pathophysiology, University of Skoplje, Yugoslavia

,

T. Memedović

¹From the Boris Kidric Institute of Nuclear Sciences, Vinca, Beograd, University of Skoplje, Yugoslavia

› Author Affiliations

Abstract

A procedure for the labelling of lyophilised Sn-Ca-Gluconate by a ^99mTc instant technique was developed. Paper and TLC chromatography and low-voltage electrophoresis were used for the determination of the labelling yield which reached between 95 to 98%. The biodistribution was followed in white (albino) rats. About 25 to 35% of the total activity of the compound was retained in the kidneys one hour after its i.v. injection.

Es wurde eine Methode zur Markierung von lyophilisiertem Sn-Ca-Glukonat unter Anwendung der ^99mTc-SofortTechnik entwickelt. Sowohl Papierund Dünnschichtchromatographie als auch Tiefspannungselektrophorese wurden für die Bestimmung der Markierungsausbeute verwendet, die zwischen 95-98% erreichte. Die Bioverteilung wurde an weißen Ratten untersucht. Etwa 25-35% der Gesamtaktivität des Präparats werden eine Stunde nach dessen intravenöser Injektion in den Nieren zurückgehalten.

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References

References
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