Nuklearmedizin 2002; 41(01): 42-46
DOI: 10.1055/s-0038-1624000
Originalarbeiten – Original Articles
Schattauer GmbH

Moyamoya syndrome: Impaired hemodynamics on ECD SPECT after EEG controlled hyperventilation

Moya-Moya-Syndrom: Beeinträchtigte Hämodynamik in der ECD-SPECT nach EEG-kontrollierter Hyperventilation
P. Matheja
1   Department of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
,
M. Weckesser
1   Department of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
,
O. Debus
2   Departement of Neuropediatrics (Head: Prof. Dr. G. Kurlemann), Münster University, Germany
,
Ch. Franzius
1   Department of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
,
J. Löttgen
1   Department of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
,
O. Schober
1   Department of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
,
G. Kurlemann
2   Departement of Neuropediatrics (Head: Prof. Dr. G. Kurlemann), Münster University, Germany
› Author Affiliations
Further Information

Publication History

Received: 20 August 2001

in revised form: 28 September 2001

Publication Date:
10 January 2018 (online)

Summary

Background and purpose: Ischemic symptoms in children with Moyamoya syndrome are typically provoked by hyperventilation (HV) and are accompanied by the “re-build-up” phenomenon in EEG. The value of scintigraphic detection of HV-provoked perfusion deficits remains to be elucidated. Patients and methods: In seven children with Moyamoya syndrome regional cerebral blood flow was assessed by 99mTc-ethyl-cysteine-dimer (ECD) single photon emission computed tomography (SPECT) after HV and under baseline conditions to identify ischemia prone regions. Results: Regional marked hypoperfusion after HV was found in all patients. Predominant perfusion deficits were detected in the frontal lobes. Conclusion: ECD SPECT is a potential tool for the preoperative evaluation of cerebral hemodynamics and for monitoring angiosurgical therapies in Moyamoya disease.

Zusammenfassung

Hintergrund und Ziel: Ischämische Symptome bei Kindern mit Moya-Moya-Erkrankung werden typischerweise durch Hyperventilation provoziert und vom Re-build-up-Phänomen im EEG begleitet. Patienten und Methoden: Bei sieben Kindern mit Moya-Moya-Syndrom wurde der regionale Blutfluss mit der 99mTc-Ethylcysteinatdimer-( ECD-)Single-Photon-Emissionscomputertomographie (SPECT) nach Hyperventilation und unter Basisbedingungen bestimmt, um ischämiegefährdete Regionen zu identifizieren. Ergebnisse: Eine regional ausgeprägte Hypoperfusion nach Hyperventilation wurde bei allen Patienten gefunden. Vorwiegend kamen Perfusionsdefekte in den Frontallappen zur Darstellung. Schlussfolgerung: ECD-SPECT eignet sich potenziell für die präoperative Evaluation der zerebralen Hämodynamik und für die Verlaufskontrolle nach gefäßchirurgischer Therapie der Moya-Moya-Erkrankung.

 
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