Gebrauch von non-steroidal antiinflammatory drugs in der Therapie primärer Kopfschmerzerkrankungen

Zusammenfassung

Seit Jahrzehnten werden non-steroidal antiinflammatory drugs (NSAID) mit großem Erfolg in der Behandlung primärer Kopfschmerzerkrankungen eingesetzt und haben einen festen Platz in der Behandlung der Migräne als auch des Kopfschmerzes vom Spannungstyp. Für die weiteren primären Kopfschmerzerkrankungen bestehen Empfehlungen, welche weiter zu einem differenzierten Gebrauch ermutigen. Trotz des Wissens über die Interaktion der NSAID mit Cyclooxygenase 1 und 2 sind noch nicht alle Mechanismen der Interaktion der NSAID mit kopfschmerzrelevanten pathophysiologischen Prozessen bekannt. Wir geben einen kurzen Überblick über die wichtigsten aktuellen Forschungsergebnisse zu NSAID und Kopfschmerzen, die Empfehlungen zum Gebrauch der NSAID zur Behandlung der primären Kopfschmerzerkrankungen und geben einen allgemeinen Überblick über die Wirkweisen und wichtigsten Nebenwirkungen der NSAID.

Summary

For decades NSAIDs are being used in the treatment of primary headache disorders with great benefit for patients. They belong to the basic treatment options for migraine as well as tension type headache. For the use of NSAIDs in the treatment of the remaining primary headaches there are data existing that support a differentiated use. Despite the knowledge of the effects of NSAIDs on cyclooxygenase 1 and 2 not all of the mechanisms of interaction with processes in headache relevant pathophysiology are understood. Here we present an overview of the newest research on NSAIDs relevant to headaches, the current guidelines for the treatment of primary headaches and their mentioning of NSAIDs, the known mechanisms of action as well as the most important side effects.

Schlüsselwörter

Kopfschmerz - NSAID - Therapie - Migräne

Keywords

Headache - NSAIDs therapy - migraine

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