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DOI: 10.1055/s-0038-1628999
Hypothermie in der Behandlung asphyktischer Neugeborener mit hypoxisch-ischämischer Enzephalopathie
Hypothermia as treatment for newborns with hypoxic-ischemic encephalopathyPublication History
Eingegangen am:
15 June 2009
angenommen am:
26 June 2009
Publication Date:
25 January 2018 (online)
Zusammenfassung
Die hypoxisch-ischämische Enzephalopathie (HIE) als Folge der perinatalen Asphyxie ist ein Krankheitsbild mit einer hohen Mortalität und führt oft zu lebenslanger Morbidität. Bis in die letzten Jahre brachte die Forschung keinen durchschlagenden Erfolg in der Behandlung des neurologischen Schadens. Mit den Erkenntnissen über den genauen Pathomechanismus werden nun immer mehr neuroprotektive Strategien getestet. Unter diesen erbrachte bisher nur die Hypothermietherapie klinische Erfolge. Studien zeigten, dass vor allem Neugeborene mit moderater Enzephalopathie von der Hypothermietherapie profitieren. Dieser Artikel geht auf die Wirkungsweise der Hypothermie ein, gibt einen Überblick über die abgeschlossenen klinischen Studien und beschreibt die praktische Durchführung der Hypothermietherapie.
Summary
Perinatal hypoxic-ischemic encephalopathy (HIE) remains an important cause of neurologic disability. The current treatment for children with hypoxic-ischemic brain injury is still supportive. In the last years neuroprotective therapy has been tested in numerous animal models. Among these, for now only the treatment with hypothermia showed benefit in clinical studies. This review gives an overview of the pathomechanism and according to this the mechanisms of action of hypothermia. Furthermore completed clinical trials and the procedure of induced hypothermia are described.
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