Genetik in der Allergologie

Zusammenfassung

In der Genetik komplexer Erkrankungen gab es in den letzten Jahren wichtige Fortschritte. Mithilfe von genomweiten Assoziationsstudien wurde neue Erkenntnisse über die Vererbung von häufigen Volkserkrankungen wie Diabetes, Rheuma und chronisch entzündli-chen Darmerkrankungen gewonnen. Auch bei Asthma und Allergien wurden diese Studien erfolgreich eingesetzt. Große Hoffungen werden an diese Studien geknüpft, auch und vor allem was die Translation der Ergebnisse in die Praxis und zum Wohl der Patienten betrifft. Wie realistisch diese Hoffnungen sind, was in den nächsten Jahren tatsächlich zu erwarten ist und was eventuell heute bereits die klinische Praxis der Allergologie und Pädiatrie betrifft, wird in dieser Übersichtsarbeit diskutiert.

Summary

Significant accomplishments have been achieved in the genetics of complex diseases in recent years. Using genome wide association studies new knowledge about the inheritance and the molecular basis of common diseases such as diabetes, rheumatoid arthritis and inflammatory bowel disease was created. Genome wide association studies were also applied successfully to asthma and allergies. Great hopes are set in these studies, especially in the potential translation of these results into practice to improve the quality of health care for the patient. How realistic these hopes are, what to expect from this new knowledge and if certain aspects of these studies may affect daily practice in paediatrics and allergology is discussed in this review.

Schlüsselwörter

Asthma - Allergie - GWAS - Genetik

Keywords

Asthma - allergy - GWAS - genetics

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