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Nuklearmedizin 1988; 27(04): 151-153
DOI: 10.1055/s-0038-1629447
Review Articles
Schattauer GmbH

On the Role of Transferrin in 67Ga Uptake by Tumor Cells

L. J. Anghileri
1   From the Nuclear Medicine Service and Biophysics Laboratory, Medical Faculty, University of Nancy, France
,
P. Thouvenot
1   From the Nuclear Medicine Service and Biophysics Laboratory, Medical Faculty, University of Nancy, France
,
F. Brunotte
1   From the Nuclear Medicine Service and Biophysics Laboratory, Medical Faculty, University of Nancy, France
,
J. Robert
1   From the Nuclear Medicine Service and Biophysics Laboratory, Medical Faculty, University of Nancy, France
› Author Affiliations
Further Information

Publication History

Received: 14 December 1987

Publication Date:
04 February 2018 (online)

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In vitro uptake of 67Ga-citrate and 59Fe-citrate by DS sarcoma cells in the presence of tumor-bearing animal blood plasma showed a dramatic inhibition of both 67Ga and 59Fe uptakes: about ii/io of 67Ga and 1/5o of the 59Fe are taken up by the cells. Subcellular fractionation appears to indicate no specific binding to cell structures, and the difference of binding seems to be related to the transferrin chelation and transmembrane transport differences

Zusammenfassung

Die In-vitro-Aufnahme von 67Ga- Zitrat und 59Fe-Zitrat durch DS-Sarkomzellen wurde in der Gegenwart von Blut tumortragender Tiere erheblich sowohl für 67Ga als auch für 59Fe unterdrückt: etwa 1/10 von 67Ga und ‘1/50von 59Fe wurden von den Zellen aufgenommen. Die subzelluläre Fraktionierung schien keine spezifische Bindung an Zellstrukturen aufzuzeigen und die Bindungsunterschiede schienen eine Beziehung zur TransferrinChelatbildung und zu transmembranösen Transportunterschieden aufzuweisen.

 

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