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Vet Comp Orthop Traumatol 2001; 14(03): 165-168
DOI: 10.1055/s-0038-1632693
Clinical Report
Schattauer GmbH

Use of osteogenic protein-1 in the management of a nonunion radial fracture in a Squirrel Monkey (Saimiri boliviensis)*

J. M. Liptak
1   Department of Veterinary Clinical Sciences, University of Sydney, Sydney, New South Wales, Australia
,
L. Vogelnest
2   Taronga Zoo, Mosman, New South Wales, Australia
,
A. J. Shimmin
3   Melbourne Orthopaedic Group, Windsor, Victoria, Australia
,
P. A. Moses
1   Department of Veterinary Clinical Sciences, University of Sydney, Sydney, New South Wales, Australia
,
D. J. Simpson
1   Department of Veterinary Clinical Sciences, University of Sydney, Sydney, New South Wales, Australia
› Author AffiliationsThis study was funded in part by Stryker Biotech, Australia. J. M. Liptak is supported by the Lionel Lonsdale Senior Clinical Fellowship.
Further Information

Publication History

Received 01 December 2000

Accepted 19 March 2001

Publication Date:
09 February 2018 (online)

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Summary

A Squirrel Monkey (Saimiri boliviensis) presented with comminuted, proximal diaphyseal fractures of the left radius and ulna which were repaired with a type II acrylic external fixateur and intramedullary pin, respectively. The external fixateur was removed six weeks postoperatively as the antebrachium was stable despite radiographic evidence that the radial fracture had failed to completely heal. Eight months postoperatively, radiographic examination revealed a nonunion fracture of the proximal radial diaphysis. The nonunion fracture was stabilised with a miniplate and screws, and osteogenic protein-1 (OP-1) (bone morphogenetic protein-7) was inserted to augment bony union. Radiographic evidence of fracture healing was present four weeks postoperatively. Bone morphogenetic proteins, in particular OP-1, can be used as a substitute for autogenous cancellous bone if there is an insufficient quantity of cancellous bone or harvesting will result in unacceptable morbidity.

Osteogenic protein-1 (OP-1 or bone morphogenetic protein 7) was used in the management of a nonunion fracture of the radius in a Squirrel Monkey (Saimiri boliviensis). Osteogenic protein-1 was used in preference to autogenous cancellous bone as the small size of the monkey would have limited the quantity of cancellous bone and predisposed to morbidity at the harvest site. This is the first report of the clinical use of OP-1 in veterinary surgery.

Keywords

Osteogenic protein-1 - bone morphogenetic proteins - nonunion fracture
 

  • REFERENCES

  • 1 Baker WH, Kang SS. Arterial injuries. In: Textbook of Surgery. (15th edn). Sabiston DC. (ed). WB Saunders, Philadelphia: 1997: 1719.
    Google Scholar
  • 2 Berend ME, Harrelson JM, Feagin JA. Fractures and dislocation: general principles. In: Textbook of Surgery. (15th edn). Sabiston DC. (ed). WB Saunders, Philadelphia: 1997: 1400.
    Google Scholar
  • 3 Bostrom MPG. Expression of bone morphogenetic proteins during fracture healing. Clin Orthop Related Res 1998; 355S: S116-23.
    CrossrefPubMedGoogle Scholar
  • 4 Boyan BD, Caplan AI, Heckman JD, Lennon DP, Ehler W, Schwartz Z. Osteochondral progenitor cells in acute and chronic canine nonunions. J Orthop Res 1999; 17: 246-55.
    CrossrefPubMedGoogle Scholar
  • 5 Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC, Whitecloud TS. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg 1994; 76A: 827-38.
    PubMedGoogle Scholar
  • 6 Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop Related Res 1994; 301: 302-12.
    PubMedGoogle Scholar
  • 7 Cook SD, Dalton JE, Tan EH, Whitecloud TS, Rueger DC. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as bone graft substitute for spinal fusions. Spine 1994; 19: 1655-63.
    CrossrefPubMedGoogle Scholar
  • 8 Cook SD, Wolfe MW, Salkeld SL, Rueger DC. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg 1995; 77A: 734-50.
    PubMedGoogle Scholar
  • 9 Cook SD, Rueger DC. Osteogenic protein-1: biology and applications. Clin Orthop 1996; 324: 29-38.
    CrossrefPubMedGoogle Scholar
  • 10 Cook SD, Salkeld SL, Brinker MR, Wolfe MW, Rueger DC. Use of an osteoconductive biomaterial (rhOP-1) in healing large segmental bone defects. J Orthop Trauma 1998; 12: 407-12.
    CrossrefPubMedGoogle Scholar
  • 11 Cook SD. Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites. Orthopedics 1999; 22: 669-71.
    PubMedGoogle Scholar
  • 12 Cunningham BW, Kanayama M, Parker LM. et al. Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine: a comparative endoscopic study using the Bagby and Kuslich interbody fusion device. Spine 1999; 24: 509-18.
    CrossrefPubMedGoogle Scholar
  • 13 Ferguson JF. Fracture of the humerus after cancellous bone graft harvesting in a dog. J Small Anim Pract 1996; 37: 232-4.
    CrossrefPubMedGoogle Scholar
  • 14 Geesink RGT, Hoefnagels NHM, Bulstra SK. Osteogenic activity of OP-1 bone morphogenetic protein-7 (BMP-7) in a human fibular defect. J Bone Joint Surg 1999; 81B: 710-8.
    PubMedGoogle Scholar
  • 15 Goldner RD, Goldner JL. Compression neuropathies of the hand and forearm. In: Textbook of Surgery. (15th edn). Sabiston DC. (ed). WB Saunders, Philadelphia: 1997: 1484-5.
    Google Scholar
  • 16 Itoh T, Mochizuki M, Fuda K. et al. Femoral non-union fracture treated with recombinant human bone morphogenetic protein-2 in a dog. J Vet Med Sci 1998; 60: 535-8.
    CrossrefPubMedGoogle Scholar
  • 17 Lane JM, Tomin E, Bostrom MPG. Biosynthetic bone grafting. Clin Orthop Related Res 1999; 367S: S107-17.
    PubMedGoogle Scholar
  • 18 Millis DL. Bone and non-bone derived growth factors and effects on bone healing. Vet Clin North Am Small Anim Clin 1999; 29: 1221-46.
    PubMedGoogle Scholar
  • 19 Paramore CG, Lauryssen C, Rauzzino MJ. et al. The safety of OP-1 for lumbar fusion with decompression – a canine study. Neurosurgery 1999; 44: 1151-6.
    CrossrefPubMedGoogle Scholar
  • 20 Reddi AH. Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop Related Res 1998; 355S: S66-S72.
    CrossrefPubMedGoogle Scholar
  • 21 Ripamonti U, van den Heever B, Sampath TK, Tucker MM, Rueger DC, Reddi AH. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors 1996; 13: 273-89.
    CrossrefPubMedGoogle Scholar
  • 22 Robello GT, Aron DN. Delayed and nonunion fractures. Sem Vet Med Surg (Small Anim) 1992; 07: 98-104.
    PubMedGoogle Scholar