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Vet Comp Orthop Traumatol 2003; 16(01): 50-58
DOI: 10.1055/s-0038-1632746
DOI: 10.1055/s-0038-1632746
Original Research
Ratite cancellous xenograft: effects on avian fracture healing
This project was supported by the Chicago Zoological Society, and the Center for Companion Animal Health, School of Veterinary Medicine, University of California-Davis.
Further Information
Publication History
Received
22 March 2002
Accepted
19 September 2002
Publication Date:
08 February 2018 (online)
Summary
A segmental radial defect model was used to radiographically and histologically evaluate response to ratite cancellous xenograft in pigeons. The control group showed little evidence of callus production with all fractures proceeding to nonunion. Lymphocytic response to xenograft peaked at four weeks and diminished thereafter. Fractures treated with cancellous xenograft had significant increases in new bone production.
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References
- 1 Aspenberg P, Lohmander LS, Thorngren KG. Failure of bone induction by bone matrix in adult monkeys. JBJS 1988; 70-B: 625-7.
- 2 Aspenberg P, Thoren K. Lipid extraction enhances bank bone incorporation. Acta Orthop Scand 1990; 61: 546-8.
- 3 Aspenberg P, Thorngren KG, Lohmander LS. Rabbit bone matrix induces bone formation in the athymic rat. Acta Orthop Scand 1988; 59: 276-8.
- 4 Bassett CA, Creighton DK. A comparison of host response to cortical autografts and processed calf heterografts. JBJS 1962; 44-A: 842-54.
- 5 Bennett RA, Kuzma AB. Fracture management in birds. J Zoo Wildlife Med 1992; 23: 5-38.
- 6 Burchardt H. Biology of bone transplantation. Orthop Clin N Amer 1987; 18: 187-196.
- 7 Chalmers J. Transplantation immunity in bone homografting. JBJS 1959; 41B: 160-79.
- 8 Chappard D, Fressonnet C, Genty C. et al. Fat in bone xenografts; importance of the purification procedures on cleanliness, wettability and biocompatability. Biomaterials 1993; 14: 507-12.
- 9 Dodds RA, Connor JR, James IE. et al. Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodelling bone. J Bone Min Res 1995; 10: 1666-80.
- 10 Ekelund A, Ahmed M, Bjurholm A. et al. Neuropeptides in heterotopic bone induced bone matrix in immunosuppressed rats. Clin Orthop 1997; 345: 229-38.
- 11 Ekelund A, Aspenberg P, Nilsson O. No effect of immunosuppression with cyclosporin A detected on bone ingrowth into cancellous alloand xenografts in rats. Acta Orthop Scand 1999; 70: 491-6.
- 12 Ekelund AL, Nilsson O. Effects of cyclosporin A on bone turnover and on resorption of demineralized bone matrix. Clin Orthop 1996; 326: 127-34.
- 13 Elves MW. Humoral response to allografts of bone. Int Arch Allergy 1974; 47: 708-15.
- 14 Elves MW, Salama R. A study of the development of cytotoxic antibodies produced in recipients of xenografts (heterografts) of iliac bone. JBJS 1974; 56B: 331-9.
- 15 Forell EB, Straw RC, Powers BE, Johnson J, Cooper MF. et al. Evaluation of the osteoinductive capacity of canine demineralized bone matrix in heterotopic muscle sites of athymic rats. Vet Comp Orthop Traumatol 1993; 06: 21-28.
- 16 Friedlaender GE, Strong DM, Sell KW. Studies on the antigenicity of bone. JBJS 1976; 58-A: 854-8.
- 17 Friedlaender GE, Strong DM, Sell KW. Studies on the antigenicity of bone. JBJS 1984; 66-A: 107-12.
- 18 Fukanaga T, Masumi S, Yano H. Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Acta Orthop Scand 1995; 66: 557-60.
- 19 Gazdag AR, Lane JM, Glaser D. et al. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg 1995; 03: 1-8.
- 20 Goldberg VM, Bos GD, Heiple KG. et al. Improved acceptance of frozen bone allografts in genetically mismatched dogs by immunosuppression. JBJS 1984; 66-A: 937-50.
- 21 Goldberg VM, Powell A, Shaffer JW. et al. Bone grafting: the role of histocompatability in transplantation. J Orthop Res 1985; 03: 389-404.
- 22 Goldberg VM, Stevenson S. Natural history of autografts and allografts. Clin Orthop 1987; 225: 7-16.
- 23 Hallen LG. Heterologous transplantation with Kiel bone. Acta Orthop Scand 1966; 37: 1-19.
- 24 Halloran PF, Lee EH, Langer F. et al. Orthotopic bone transplantation in mice. Transplantation 1979; 27: 420-6.
- 25 Hauschka PV, Mavrakos AE, Iafrati MD. et al. Growth factors in bone matrix. J Biol Chem 1986; 261: 12665-74.
- 26 Heiple KG, Kendrick RE, Herndon CH. et al. A critical evaluation of processed calf bone. JBJS 1967; 49-A: 1119-27.
- 27 Horowitz MC, Friedlaender GE. The immune response to bone grafts. In: Bone and cartilage allografts: biology and clinical applications. Friedlander GE, Goldberg VM. (eds). American Academy of Orthopaedic Surgeons; Park Ridge, IL: 1991: 85-101.
- 28 Horowitz MC, Friedlander GE. Induction of specific t-cell responsiveness to allogeneic bone. JBJS 1991; 73-A: 1157-68.
- 29 Karges DE, Anderson KJ, Dingwall JA. et al. Experimental evaluation of processed heterogenous bone transplants. Clin Orthop 1963; 29: 230-47.
- 30 Kerwin SC, Lewis DD, Elkins AD. et al. Deepfrozen allogeneic cancellous bone grafts in 10 dogs: a case series. Vet Surg 1996; 25: 18-28.
- 31 Kamijou T, Nakajima T, Ozawa H. Effects of osteocytes on osteoinduction in the autogenous rib graft in the rat mandible. Bone 1994; 15: 629-37.
- 32 Kramer IRH, Killey HC, Wright HC. The response of the rabbit to implants of processed calf bone (Boplant). Archs Oral Biol 1968; 13: 1263-73.
- 33 Langer F, Czitrom A, Pritzker KP. et al. The immunogenicity of fresh and frozen allogeneic bone. JBJS 1975; 57-A: 216-20.
- 34 Leeds EB. Tibial fracture repair in a doublewaddled cassowary. J Vet Orthop 1979; 01: 21-7.
- 35 Linn KA, Paul-Murphy J, Edwards RB. et al. Use of bone morphogenic protein-2 to promote healing of fracture gaps in pigeons. ACVS Proceedings; 2001. Chicago: 12-13. (abstr).
- 36 MacCoy DM. Techniques of fracture treatment in birds and their indications: external and internal fixation. In: Proceedings of the First International Conference on Zoological and Avian Medicine. 1987. Oahu: Omnipress, Madison, WI; 562-3.
- 37 MacCoy DM, Hascheck WM. Healing of transverse humeral fractures in pigeons treated with ethylene oxide-sterilized, dry stored, onlay cortical xenografts and allografts. Am J Vet Res 1988; 49: 106-111.
- 38 Muscolo DL, Kawai S, Ray RD. Cellular and humoral response analysis of bone-allografted rats. JBJS 1976; 58-A: 826-32.
- 39 Pieron AP, Bigelow D, Hamonic M. Bone grafting with boplant. JBJS 1968; 50B: 364-8.
- 40 Plenk H, Hollmann K, Wifert KH. Experimental bridging of osseous defects in rats by the implantation of Kiel bone containing fresh autologous marrow. JBJS 1972; 54B: 735-43.
- 41 Reddi AH, Wientroub S, Muthukumaran N. Biologic principles of bone induction. Orth Clin NA 1987; 18: 207-12.
- 42 Redig PT. A clinical review of orthopedic techniques used in the rehabilitation of raptors. In: Wild Bird Medicine - A Course in Avian Physiology, Medicine, and Surgery. Redig PY, Duke GE. (eds) 1987: 83-98.
- 43 Redig P, Roush JC. Orthopedic and soft tissue surgery in raptorial birds. In: Zoo and Wild Animal Medicine. 1st edn. Fowler M. (ed). WB Saunders; 1978: 246-53.
- 44 Roush JC. Avian orthopedics. In: Current Veterinary Therapy VII, Small Animal Practice. Kirk RW. (ed), 1980. WB Saunders; Philadelphia; 672.
- 45 Salama R. Xenogeneic bone grafting in humans. Clin Orthop 1983; 174: 113-21.
- 46 Salama R, Burwell RG, Dickson IR. Recombined grafts of bone and marrow. JBJS 1973; 55-B: 402-17.
- 47 Salama R, Gazil E. The antigenicity of Kiel bone in the human host. JBJS 1978; 60B: 262-5.
- 48 Sinibaldi KR. Bone grafting principles. In: Current techniques in small animal surgery. edn 4. Bojrab MJ. (ed). Baltimore: Williams & Wilkins; 1998: 901-5.
- 49 Stevenson S. Enhancement of fracture healing with autogenous and allogeneic bone grafts. Clin Orthop 1998; 355S: 239-46.
- 50 Stevenson S, Hohn RB, Templeton JW. Effects of tissue antigen matching on the healing of fresh cancellous bone allografts in dogs. Am J Vet Res 1983; 44: 201-6.
- 51 Stevenson S, Li XQ, Martin B. The fate of cancellous and cortical bone after transplantation of fresh and frozen tissue-antigen matched and mismatched osteochondral allografts in dogs. JBJS 1991; 73-A: 1143-56.
- 52 Stevenson S, Shaffer JW, Goldberg VM. The humoral response to vascular and nonvascular allografts of bone. Clin Orthop 1996; 323: 86-95.
- 53 Strong DM, Friedlaender GE, Tomford WW. et al. Immunologic responses in human recipients of osseous and osteochondral allografts. Clin Orthop 1996; 326: 107-14.
- 54 Thielemann FW, Spaeth G, Veihelmann D. et al. Osteoinduction. Part I: Test model and comparative long term observation of allogenic and xenogenic matrix implants. Arch Orthop Trauma Surg 1982; 99: 217-22.
- 55 Thoren K, Aspenberg P, Thorngren KG. Lipid extraction decreases the specific immunologic response to bone allografts in rabbits. Acta Orthop Scand 1993; 64: 44-6.
- 56 Wander KW, Schwarz PD, James SP. et al. Fracture healing after stabilization with intramedullary xenograft cortical bone pins: a study in pigeons. Vet Surg 2000; 29: 237-44.
- 57 Wilson JW, Rhinelander FW, Stewart CL. Vascularization of cancellous chip bone grafts. Am J Vet Res 1985; 46: 1691-9.