Summary
Objective Summarize the current state bioinformatics research from the published literature
in 2008.
Methods The entire corpus of publications indexed by the National Library of Medicine in
the PubMed repository was reviewed for articles tagged as belonging to the discipline
of bioinformatics by Medical Subject Heading or by term in the title or abstract of
the article. Selected summary statistics of this corpus were then used to motivate
additional exploration.
Results Over ten thousand articles published in 2008 populated the bioinformatics corpus.
Significantly, there were at least as many publications in genomics and genetics that
used computational techniques but that were not identified as bioinformatics research.
Genomics and proteomics continued to be the leading application domains of bioinformatics
research but despite the proliferation of human studies, the genes most studied in
the corpus were from yeast rather than the human organism. The growth in the genomic
studies of human disease was accompanied by a growing critical literature regarding
the methods, results and impact of these studies. Concurrently, the availability of
full genome sequences at commodity prices has increased the computational challenges
of human studies by several orders of magnitude. Further concerns were raised about
the consequences of public disclosure of comprehensive or even aggregate genomic data.
Conclusion The impressive size of the bioinformatics bibliome is easily dwarfed by the challenges
generated by the continued increased growth of high-throughput biological data sets.
The demand for bioinformatics expertise and tools is therefore likely to continue
to increase, at least in the near term.
Keywords
Bioinformatics - publications - genomics - proteomics - computational biology
