CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2018; 07(03): 253-255
DOI: 10.1055/s-0038-1639386
Case Report
Neurological Surgeons' Society of India

Intraoperative Fluorescence Is Useful but Not Always Sufficient in Contrast-Enhancing Malignant Gliomas

Aliasgar V. Moiyadi
1  Division of Neurosurgery, Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
› Author Affiliations
Funding None.
Further Information

Publication History

Received: 07 August 2017

accepted: 04 September 2017

Publication Date:
10 April 2018 (online)



Fluorescence-guided resections have become standard of care for malignant gliomas. Strong fluorescence has been shown to correlate with solid enhancing tumor. However, with experience it has also been shown that visualized fluorescence may not identify the entire extent of the tumor. Knowing that malignant gliomas extend beyond the contrast-enhancing tumor seen on magnetic resonance imaging (MRI), reliance only on the fluorescence intraoperatively may not be enough. Intraoperative ultrasound is a readily available tool for real-time assessment of resection status, irrespective of the tumor type. We describe one such case in which after resecting all the visible fluorescing tumor component, we identified a significant component of nonfluorescing tumor, using intraoperative ultrasound that was further resected completely. This illustrates the need for multimodal intraoperative guidance for achieving optimal tumor resection in malignant gliomas.