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DOI: 10.1055/s-0038-1639790
WNT1-inducible signaling protein-1 in chronic rhinosinusitis with nasal polyps
Aim:
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal cavity and sinuses. We have recently shown that canonical Wnt signaling is up-regulated in CRSwNP and that activation of canonical Wnt signaling in nasal epithelial cell cultures leads to cytokine release and a spectrum of changes consistent with those seen during epithelial remodeling of the nasal mucosa. The aim of this study was to elucidate the role of the WNT pathway target WISP1 in nasal polyps of CRSwNP.
Methods:
Microarray, RT-qPCR and immunohistochemistry from nasal polyps and inferior turbinates. Cell culture experiments with human nasal epithelial cells and fibroblasts.
Results:
WISP1 gene expression is significantly up-regulated in nasal polyps compared to inferior turbinate control tissue. We show that WNT1-inducible signaling protein-1 is differentially expressed in nasal polyps. Data from cell culture experiments will be presented.
Conclusion:
We hypothesize that up-regulation of WISP1 in the nasal mucosa contributes to the progression of CRSwNP.
Publication History
Publication Date:
18 April 2018 (online)
© 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Georg Thieme Verlag KG
Stuttgart · New York