Subscribe to RSS
Autoimmune pathogenesis in chronic obstructive tube ventilation disorder
18 April 2018 (online)
The causes of tube dysfunction can be diverse and are often due to an obstructed nasopharynx, in bacterial or in viral infections. In particular, patients with chronic tube dysfunction often have none of these pathophysiological causes. The aim of this study was therefore to examine patients with chronic tube dysfunction for possible autoimmune pathophysiological causes.
In the serum of 31 patients with chronic tube dysfunction, in addition to various ELISA tests, an additional determination of antinuclear antibody- (ANA-) titers was carried out. As a healthy comparison cohort served 92 blood donors. The investigations were carried out between March 2014 and December 2016.
In the study group, an ANA titer ≥1:320 was measured in 13 out of 31 patients (41.9%). In the control group, an ANA titer ≥1:320 was found in 14 of 92 blood donors (15.22%). If the cutoff for a pathological ANA titer is defined at 1:320, the results of the patients with chronic tube dysfunction in the chi-square test with Yates correction are statistically significantly different from those of the blood donors (p-value 0.0043).
In patients with chronic tubal dysfunction autoimmune pathogenesis could be the cause of the complaints. Since this could have therapeutic consequences, further research would be needed to confirm this hypothesis.