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DOI: 10.1055/s-0038-1640813
Genetic polymorphism of tumor necrosis factor alpha in patients with bilateral nasal polyps with and without bronchial asthma
Introduction:
Nasal polyposis has a clear association with bronchial asthma, aspirin sensitivity, and cystic fibrosis. Some studies have associated the TNF-α 2308Aallele with asthma and increased bronchial responsiveness. A link has been demonstrated recently between TNF-α 2308Aallele pleomorphism and nasal polyps.
In our study we aimed to identify if genetic polymorphism of TNF-α in patients with bilateral nasal polyps can be used as a prognostic factor for the development of asthma.
Methods:
Genomic DNA analysis and genotyping of the TNF-a-2308 G/A polymorphism in patients with nasal polyps and those with nasal polyps associated with bronchial asthma.
Results:
We found no statistically significant difference between the control group and patient with nasal polyps. We also found no significant difference between the control group and patient with nasal polyps associated with bronchial asthma. We found no statistically significant difference between patients with nasal polyps and those with nasal polyps associated with bronchial asthma.
Conclusion:
This study did not demonstrate a significant rule of TNF- α pleomorphism as a prognostic factor for development of bronchial asthma in patients with nasal polyps.
Publication History
Publication Date:
18 April 2018 (online)
© 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Georg Thieme Verlag KG
Stuttgart · New York