Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00034916.xml
Download PDF
Nervenheilkunde 2018; 37(01/02): 43-49
DOI: 10.1055/s-0038-1642077
DOI: 10.1055/s-0038-1642077
Kopfschmerz
Das reversible zerebrale Vasokonstriktionssyndrom
Als Ursache von Donnerschlagkopfschmerzen unterschätzt?The reversible cerebral vasoconstriction syndromeAn underestimated cause of thunderclap headache?Further Information
Publication History
eingegangen am:
04 October 2017
angenommen am:
23 October 2017
Publication Date:
30 March 2018 (online)
Zusammenfassung
Das reversible zerebrale Vasokonstriktionssyndrom (RCVS) ist eine häufige, wahrscheinlich unterdiagnostizierte Ursache des Donnerschlagkopfschmerzes. Typischerweise präsentiert sich das RCVS mit einem stärksten, innerhalb von weniger als 1 Minute sein Maximum erreichenden Kopfschmerz. Dieser kann innerhalb von wenigen Wochen, oft getriggert durch körperliche Anstrengung, emotionale Belastung oder Valsalva-Manöver, immer wieder auftreten. Die Erkrankung verläuft meist monosymptomatisch, selbstlimitierend und benigne, allerdings können intrazerebrale Blutungen, Ischämien oder ein PRES komplizierend auftreten. Im folgenden Artikel sollen die typische Präsentation des RCVS, Komplikationen, Verlauf, Therapie und Pathophysiologie vorgestellt werden.
Summary
The reversible cerebral vasoconstriction syndrome (RCVS) is a common but probably underdiagnosed cause of thunderclap headache. Typically, the RCVS presents with an excruciating headache reaching its peak within a minute. The headache can reoccur for several weeks triggered by exertion, emotions or Valsalva’s manoeuvres. The course of the disease is mostly monosymptomatic and benign, although accompanying symptoms like intracerebral haemorrhage, stroke or PRES are possible. In this review the typical presentation of RCVS, complications, course, management and pathophysiology are described.
-
Literatur
- 1 Calabrese LH, Dodick DW, Schwedt TJ, Singhal AB. Narrative Review: Reversible Cerebral Vasoconstriction SyndromesReversible Cerebral Vasoconstriction Syndromes. Annals of internal medicine 2007; 146 (01) 34-44.
- 2 Society HCCotIH The international classification of headache disorders, (beta version). Cephalalgia. 2013
- 3 Chen SP, Fuh JL, Wang SJ. Reversible cerebral vasoconstriction syndrome: current and future perspectives. Expert review of neurotherapeutics. 2011
- 4 Ducros A. Reversible cerebral vasoconstriction syndrome. The Lancet Neurology 2012; 11 (10) 906-17.
- 5 Chen SP, Fuh JL, Wang SJ. Reversible cerebral vasoconstriction syndrome: an under-recognized clinical emergency. Therapeutic advances in neurological disorders 2010; 03 (03) 161-71.
- 6 Ducros A, Wolff V. The typical thunderclap headache of reversible cerebral vasoconstriction syndrome and its various triggers. Headache: The Journal of Head and Face Pain 2016; 56 (04) 657-73.
- 7 Grooters GS, Sluzewski M, Tijssen CC. How often is thunderclap headache caused by the reversible cerebral vasoconstriction syndrome?. Headache: The Journal of Head and Face Pain 2014; 54 (04) 732-5.
- 8 Yeh YC, Fuh JL, Chen SP, Wang SJ. Clinical features, imaging findings and outcomes of headache associated with sexual activity. Cephalalgia 2010; 30 (11) 1329-35.
- 9 Singhal AB, Hajj-Ali RA, Topcuoglu MA, Fok J, Bena J, Yang D. et al. Reversible cerebral vasoconstriction syndromes: analysis of 139 cases. Archives of neurology 2011; 68 (08) 1005-12.
- 10 Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain 2007; 130 (12) 3091-101.
- 11 Chen SP, Fuh JL, Chang FC, Lirng JF, Shia BC, Wang SJ. Transcranial color doppler study for reversible cerebral vasoconstriction syndromes. Annals of neurology 2008; 63 (06) 751-7.
- 12 Muehlschlegel S, Kursun O, Topcuoglu MA, Fok J, Singhal AB. Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage. JAMA neurology 2013; 70 (10) 1254-60.
- 13 Miller T, Shivashankar R, Mossa-Basha M, Gandhi D. Reversible cerebral vasoconstriction syndrome, part 1: epidemiology, pathogenesis, and clinical course. American Journal of Neuroradiology 2015; 36 (08) 1392-9.
- 14 Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ. Recurrent primary thunderclap headache and benign CNS angiopathy Spectra of the same disorder?. Neurology 2006; 67 (12) 2164-9.
- 15 Ducros A, Fiedler U, Porcher R, Boukobza M, Stapf C, Bousser MG. Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome. Stroke 2010; 41 (11) 2505-11.
- 16 Miller T, Shivashankar R, Mossa-Basha M, Gandhi D. Reversible cerebral vasoconstriction syndrome, part 2: diagnostic work-up, imaging evaluation, and differential diagnosis. American Journal of Neuroradiology 2015; 36 (09) 1580-8.
- 17 Calic Z, Cappelen CSmith, Zagami A. Reversible cerebral vasoconstriction syndrome. Internal medicine journal 2015; 45 (06) 599-608.
- 18 Singhal AB, Topcuoglu MA. Glucocorticoid-associated worsening in reversible cerebral vasoconstriction syndrome. Neurology 2017; 88 (03) 228-36.
- 19 John S, Singhal AB, Calabrese L, Uchino K, Hammad T, Tepper S. et al. Long-term outcomes after reversible cerebral vasoconstriction syndrome. Cephalalgia 2016; 36 (04) 387-94.
- 20 Obusez E, Hui F, Hajj-Ali R, Cerejo R, Calabrese L, Hammad T. et al. High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. American Journal of Neuroradiology 2014; 35 (08) 1527-32.
- 21 Dodick DW, Brown R, Britton JW, Huston J. Nonaneurysmal thunderclap headache with diffuse, multifocal, segmental, and reversible vasospasm. Cephalalgia 1999; 19 (02) 118-23.
- 22 Chen SP, Fuh JL, Wang SJ, Chang FC, Lirng JF, Fang YC. et al. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Annals of neurology 2010; 67 (05) 648-56.
- 23 Dodick DW. Thunderclap headache. Journal of Neurology, Neurosurgery & Psychiatry 2002; 72 (01) 6-11.
- 24 Chen SP, Wang YF, Huang PH, Chi CW, Fuh J-L, Wang SJ. Reduced circulating endothelial progenitor cells in reversible cerebral vasoconstriction syndrome. The journal of headache and pain 2014; 15 (01) 82.
- 25 Chen SP, Fuh JL, Wang SJ, Tsai SJ, Hong CJ, Yang AC. Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes. PLoS One 2011; 06 (03) e18024.
- 26 Kasselman LJ, Sideris A, Bruno C, Perez WR, Cai N, Nicoletti JN. et al. BDNF: a missing link between sympathetic dysfunction and inflammatory disease?. Journal of neuroimmunology 2006; 175 (01) 118-27.
- 27 Zukowska Z, Pons J, Lee EW, Li L. Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system?. Canadian journal of physiology and pharmacology 2003; 81 (02) 89-94.
- 28 Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF. et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular psychiatry 2010; 15 (08) 810.
- 29 Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL, Wang SJ. Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Radical Biology and Medicine 2013; 61: 243-8.
- 30 Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M. et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. New England Journal of Medicine 2015; 373 (10) 929-38.
- 31 Schneider B, Athanasiadis A, Stöllberger C, Pistner W, Schwab J, Gottwald U. et al. Gender differences in the manifestation of tako-tsubo cardiomyopathy. International journal of cardiology 2013; 166 (03) 584-8.
- 32 Bybee KA, Prasad A. Stress-related cardiomyopathy syndromes. Circulation 2008; 118 (04) 397-409.
- 33 John S, Hajj-Ali RA, Min D, Calabrese LH, Cerejo R, Uchino K. Reversible cerebral vasoconstriction syndrome: Is it more than just cerebral vasoconstriction?. Cephalalgia 2015; 35 (07) 631-4.
- 34 Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. The Lancet Neurology 2015; 14 (09) 914-25.
- 35 Feil K, Forbrig R, Thaler FS, Conrad J, Heck S, Dorn F. et al. Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome associated with intracranial hypotension. Neurocritical care 2017; 26 (01) 103-8.