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Thromb Haemost 1994; 71(03): 353-356
DOI: 10.1055/s-0038-1642442
Original Article
Schattauer GmbH Stuttgart

Collagen Induces Normal Signal Transduction in Platelets Deficient in CD36 (Platelet Glycoprotein IV)

James L Daniel
The Department of Pharmacology and Thrombosis Research Center, Temple University Medical School, Philadelphia, PA, USA
,
Carol Dangelmaier
The Department of Pharmacology and Thrombosis Research Center, Temple University Medical School, Philadelphia, PA, USA
,
Robert Strouse
The Department of Pharmacology and Thrombosis Research Center, Temple University Medical School, Philadelphia, PA, USA
,
J Bryan Smith
The Department of Pharmacology and Thrombosis Research Center, Temple University Medical School, Philadelphia, PA, USA
› Author Affiliations
Further Information

Publication History

Received: 02 June 1993

Accepted after revision 19 September 1993

Publication Date:
06 July 2018 (online)

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Summary

The receptor involved in platelet activation by collagen has not been identified. Platelet glycoprotein IV, now known as CD36, has been implicated in interaction with collagen and also been shown to be associated with intracellular tyrosine kinases. In order to investigate the possible role of collagen-mediated signal transduction via CD36, platelets were obtained from a donor that were deficient in CD36. The collagen-induced intracellular mobilization of Ca2+ in the CD36 deficient cells was of the same magnitude as that seen in platelets from normal donors. In addition, serotonin secretion did not appear to be impaired. Tyrosine phosphorylation was also comparable between the CD36-deficient and normal platelets. Thus, it is unlikely that CD36 plays a major role in collagen-dependent platelet signal transduction.

 

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