Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

Masahide Yamazaki; Hidesaku Asakura; Hiroshi Jokaji; Masanori Saito; Chika Uotani; Ichiro Kumabashiri; Eriko Morishita; Keiji Aoshima; Takayuki Ikeda; Tamotsu Matsuda

doi:10.1055/s-0038-1642454

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1994; 71(04): 424-427
DOI: 10.1055/s-0038-1642454

Review Article

Schattauer GmbH Stuttgart

Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

Masahide Yamazaki

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

²The department of Internal Medicine, Tsuruga City Hospital, Tsuruga, Japan

,

Hidesaku Asakura

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Hiroshi Jokaji

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Masanori Saito

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Chika Uotani

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Ichiro Kumabashiri

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Eriko Morishita

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Keiji Aoshima

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

,

Takayuki Ikeda

²The department of Internal Medicine, Tsuruga City Hospital, Tsuruga, Japan

,

Tamotsu Matsuda

¹The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

› Institutsangaben

Abstract

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Summary

The mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

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Referenzen

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