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Thromb Haemost 1994; 71(05): 684-691
DOI: 10.1055/s-0038-1642505
Review Article
Schattauer GmbH Stuttgart

Factors Involved In the Plasminogen Activation System in Human Breast Tumours

László Damjanovich
1   The First Department of Surgery, University School of Medicine, Debrecen, Hungary
,
Csaba Turzó
2   Department of Pathology, University School of Medicine, Debrecen, Hungary
,
Róza Ádány
3   Department of Hygiene and Epidemiology, University School of Medicine, Debrecen, Hungary
› Author Affiliations
Further Information

Publication History

Received: 31 December 1992

Accepted after revision 10 February 1994

Publication Date:
26 July 2018 (online)

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Summary

The plasminogen activation system is a delicately balanced assembly of enzymes which seems to have primary influence on tumour progression. The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators (urokinase type; u-PA and tissue type; t-PA) and their inhibitors (type 1 and 2 plasminogen activator inhibitors; PAI-1 and PAI-2). The purpose of this study was to determine the exact histological localization of all the major factors involved in plasminogen activation, and activation inhibition (plasmin system) in benign and malignant breast tumour samples. Our results show that factors of the plasmin system are present both in benign and malignant tumours. Cancer cells strongly labelled for both u-PA and t-PA, but epithelial cells of fibroadenoma samples were also stained for plasminogen activators at least as intensively as tumour cells in cancerous tissues. In fibroadenomas, all the epithelial cells were labelled for PAM. Staining became sporadic in malignant tumours, cells located at the periphery of tumour cell clusters regularly did not show reaction for PAI-1. In the benign tumour samples the perialveolar connective tissue stroma contained a lot of PAI-1 positive cells, showing characteristics of fibroblasts; but their number was strongly decreased in the stroma of malignant tumours. These findings indicate that the higher level of u-PA antigen, detected in malignant breast tumour samples by biochemical techniques, does not necessarily indicate increased u-PA production by tumour cells but it might be owing to the increased number of cells producing u-PA as well. In malignant tumours PAI-1 seems to be decreased in the frontage of malignant cell invasion; i.e. malignant cells at the host/tumour interface do not express PAI-1 in morphologically detectable quantity and in the peritumoural connective tissue the number of fibroblasts containing PAI-1 is also decreased.

 

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