Increased Response to Arachidonic Acid and U-46619 and Resistance to Inhibitory Prostaglandins in Patients with Chronic Myeloproliferative Disorders

Sergio Cortelazzo; Monica Galli; Donatella Castagna; Piera Viero; Giovanni de Gaetano; Tiziano Barbui

doi:10.1055/s-0038-1642568

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 59(01): 073-076
DOI: 10.1055/s-0038-1642568

Review Article

Schattauer GmbH Stuttgart

Increased Response to Arachidonic Acid and U-46619 and Resistance to Inhibitory Prostaglandins in Patients with Chronic Myeloproliferative Disorders

Authors

Sergio Cortelazzo

^*The Reparto di Ematologia, Ospedali Riuniti di Bergamo, Italy
Monica Galli

^*The Reparto di Ematologia, Ospedali Riuniti di Bergamo, Italy
Donatella Castagna

^*The Reparto di Ematologia, Ospedali Riuniti di Bergamo, Italy
Piera Viero

^*The Reparto di Ematologia, Ospedali Riuniti di Bergamo, Italy
Giovanni de Gaetano

^**The Reparto di Ematologia, Ospedali Riuniti di Bergamo and Istituto di Ricerche Farmacologiche “Mario Negri“, Centro di Ricerche del Consorzio “Mario Negri Sud”, S. Maria Imbaro, Chieti, Italy
Tiziano Barbui

^*The Reparto di Ematologia, Ospedali Riuniti di Bergamo, Italy

Abstract

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Summary

In patients with myeloproliferative disorders (MPD) a group of related diseases of the bone marrow stem cell and recurrent haemorrhagic and/or thrombotic complications, the production of aggregating prostaglandins (PGs) may be normal or slightly reduced, while PGI₂ production is normal. However, MPD platelet sensitivity to antiaggregatory PGs is still unknown.

We studied the potency of PGD₂, PGI₂ and PGEi as inhibitors of platelet aggregation induced by threshold aggregating concentrations of arachidonic acid and U-46619-analogue of the cyclic endoperoxide PGH₂ in 20 patients with MPD in comparison with healthy controls, with the aim of evaluating the sensitivity of MPD platelets to antiaggregatory PGs. In these patients platelet prostanoid metabolism was normal. However, the functional response of platelets to aggregating and antiaggregating prostanoids was shifted towards potentially increased platelet aggregation response. These findings could have a clinical relevance in view of the haemostatic and thrombotic complications so frequent in MPD.

Keywords

Sensitivity - aggregating and antiaggregatory prostaglandins - Thrombotic - haemorrhagic complications - Chronic myeloproliferative disorders

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References

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