Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Michael L Selley; Julie A McGuiness; Lynn A Jenkin; Mark R Bartlett; Neville G Ardlie

doi:10.1055/s-0038-1642743

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 59(02): 143-146
DOI: 10.1055/s-0038-1642743

Original Articles

Schattauer GmbH Stuttgart

Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Michael L Selley

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Julie A McGuiness

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Lynn A Jenkin

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Mark R Bartlett

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Neville G Ardlie

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

› Author Affiliations

Abstract

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Summary

4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A₂ formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at HNE concentrations in the range 10-100 μM. Platelet responses to collagen, epinephrine and arachidonic acid were not affected by PINE. Concentrations of HNE in excess of 100 pM inhibited platelet activation. HNE increased the release of ³H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin or ADR It is proposed that HNE may play an important role in controlling platelet function by regulating the activity of phospholipase A₂.

Keywords

Platelet - 4-Hydroxy-2,3-trans-nonenal-lipid peroxidation

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References

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