Cytomegalovirus Alters the von Willebrand Factor Content in Human Endothelial Cells

C A Bruggeman; W H M Debie; A D Muller; B Schutte; M CE van Dam-Mieras

doi:10.1055/s-0038-1642767

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 59(02): 264-268
DOI: 10.1055/s-0038-1642767

Original Articles

Schattauer GmbH Stuttgart

Cytomegalovirus Alters the von Willebrand Factor Content in Human Endothelial Cells

C A Bruggeman

¹The Dept. of Medical Microbiology, University of Limburg, Maastricht, The Netherlands

,

W H M Debie

¹The Dept. of Medical Microbiology, University of Limburg, Maastricht, The Netherlands

,

A D Muller

²The Dept, of Biochemistry, University of Limburg, Maastricht, The Netherlands

,

B Schutte

³The Dept, of Internal Medicine, University of Limburg, Maastricht, The Netherlands

,

M CE van Dam-Mieras

⁴The Open University, Heerlen, The Netherlands

› Author Affiliations

Abstract

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Summary

Cultured human endothelial cells were infected with human cytomegalovirus AD 169 and Kerr. The infection resulted in the appearance of viral antigens in the nuclei of about 10% of the endothelial cells and in the concomittant disappearance of vWF from the infected cells. No differences were observed between endothelial cells from different sources (umbilical cord veins or arteries, adult veins).

Keywords

von - Willebrand factor - Cytomegalovirus - Endothelial cells

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References

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