Thromb Haemost 1990; 63(03): 356-360
DOI: 10.1055/s-0038-1645046
Original Article
Schattauer GmbH Stuttgart

Relation of Intraperitoneal and Intravascular Coagulation and Fibrinolysis Related Antigens in Peritoneal Dialysis

E Gries
The Medical Laboratory Dr. Gries, Munich, FRG
,
J Kopp
*  VIth Department of Medicine, Städtisches Krankenhaus M.-Schwabing, Munich, FRG
,
U Thomae
*  VIth Department of Medicine, Städtisches Krankenhaus M.-Schwabing, Munich, FRG
,
H Kuhlmann
*  VIth Department of Medicine, Städtisches Krankenhaus M.-Schwabing, Munich, FRG
› Author Affiliations
Further Information

Publication History

Received 26 September 1989

Accepted after revision 23 January 1990

Publication Date:
30 June 2018 (online)

Summary

Patients received 2,000 ml of dialysate intraperitoneally with five exchanges per day during continuous peritoneal dialysis (CAPD) for the treatment of terminal renal insufficiency. During a dwell time of 4 h the dialysate reached a total protein concentration up to 100 mg/dl by mass transfer of intravascular proteins. The composition is dependent on the molecular weight of the proteins. This results in an intraperitoneal hemostatic system of low concentration and different composition.

We found an intraperitoneal fibrinogen cleavage and thrombin- antithrombin Ill-complex formation leading to increased levels of fibrinopeptide A (FPA: 33.3 ± 7.0 ng/ml) and thrombin-antithrombin Ill-complex (TAT: 4.7 ± 0.4 ng/ml) in plasma by mass transfer from dialysate to plasma. t-PA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor type 1) concentrations in plasma were within the normal range. The dialysate concentrations indicated a low local secretion. The fibrinolytic fibrin fragment D-dimer and the fibrinogen degradation product concentrations in plasma were greater than in dialysate. But the relations of the proteins between plasma and dialysate refer to a local intraperitoneal production as well.

The results show that intraperitoneal coagulation predominates over fibrinolysis which is accompanied by an intravascular fibrinolysis in patients undergoing CAPD. Neoantigens produced in dialysate and diffused to plasma are comparable to changes seen in disseminated intravascular coagulation.