Thromb Haemost 1990; 63(03): 472-475
DOI: 10.1055/s-0038-1645068
Original Article
Schattauer GmbH Stuttgart

Impaired Fibrinolytic Capacity in Patients with Inflammatory Bowel Disease

J C Gris
The Department of Haematology, University Hospital, Nîmes, France
,
J F Schved
The Department of Haematology, University Hospital, Nîmes, France
,
C Raffanel
*  The Department of Gastroenterology-Hepatology, University Hospital, Nîmes, France
,
A Dubois
*  The Department of Gastroenterology-Hepatology, University Hospital, Nîmes, France
,
P Aguilar-Martinez
The Department of Haematology, University Hospital, Nîmes, France
,
A Arnaud
The Department of Haematology, University Hospital, Nîmes, France
,
N Sanchez
The Department of Haematology, University Hospital, Nîmes, France
,
C Sarlat
The Department of Haematology, University Hospital, Nîmes, France
,
J L Balmès
*  The Department of Gastroenterology-Hepatology, University Hospital, Nîmes, France
› Author Affiliations
Further Information

Publication History

Received 26 July 1989

Accepted after revision 09 February 1990

Publication Date:
30 June 2018 (online)

Summary

The venous occlusion test was applied to 17 patients with inflammatory bowel disease (IBD; 7 cases of Crohn’s disease, 10 cases of ulcerative colitis). Results were compared to those obtained in 20 healthy matched control subjects. Patients with IBD had significantly decreased t-PA Ag release (p <0.001) and had no significant vWF Ag release. Residual PAI activity was evidenced after venous stasis in the IBD group but not in the control group. Hypofibrinolysis was more important in patients with an evolutive IBD than in patients with IBD in remission. Impaired systemic fibrinolytic capacity might contribute to an increased risk for thromboembolic complications and to the pathogenesis of inflammatory bowel disease.