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Thromb Haemost 1993; 70(01): 177-179
DOI: 10.1055/s-0038-1646184
State-of-the-Art Lecture
Growth Factors
Schattauer GmbH Stuttgart

TGF-β: Structure, Function, and Formation

Daniel B Rifkin
Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, and the Raymond and Beverly Sackler Laboratory, New York, NY, USA
,
Soichi Kojima
Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, and the Raymond and Beverly Sackler Laboratory, New York, NY, USA
,
Mayumi Abe
Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, and the Raymond and Beverly Sackler Laboratory, New York, NY, USA
,
John G Harpel
Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, and the Raymond and Beverly Sackler Laboratory, New York, NY, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

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  • References

  • 1 Massague J. The transforming growth factor-β family. Ann Rev Cell Biol 1990; 6: 597
    CrossrefPubMedGoogle Scholar
  • 2 Roberts AB, Sporn MB. The transforming growth factor-βs. In: Peptide Growth Factors and Their Receptors I. Sporn MB, Roberts AB. (eds) Springer-Verlag; Berlin: 1990: 419-472
    Google Scholar
  • 3 Wakefield LM, Smith DM, Flanders KC, Sporn MB. Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences. J Biol Chem 1988; 263: 7646
    PubMedGoogle Scholar
  • 4 Pircher R, Jullien J, Lawrence DA. β-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex. Biochem Biophys Res Comm 1986; 136: 30
    CrossrefPubMedGoogle Scholar
  • 5 Miyazono K, Hellman U, Wernstedt C, Heldin CH. Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem 1988; 263: 6407
    PubMedGoogle Scholar
  • 6 Kanzaki T, Olofsson A, Moren A, Werstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH. TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences. Cell 1990; 61: 1051-1061
    CrossrefPubMedGoogle Scholar
  • 7 Andres JL, Stanley K, Cheifetz S, Massague J. Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta. J Cell Biol 1989; 109: 31317-31345
    PubMedGoogle Scholar
  • 8 Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. Expression cloning and characterization of the TGF-β type III receptor. Cell 1991; 74: 797
    PubMedGoogle Scholar
  • 9 Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, and Lodish HF. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992; 68: 775-785
    CrossrefPubMedGoogle Scholar
  • 10 Border WA, Noble NA, Yamamoto T, Tomooka S, Kajami S. Antagonists of transforming growth factor-beta: a novel approach to treatment of glomerulonephritis and prevention of glomerulosclerosis. Kidney International 1992; 41: 566
    CrossrefPubMedGoogle Scholar
  • 11 Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol 1989; 109: 309
    CrossrefPubMedGoogle Scholar
  • 12 Sato Y, Tsuboi R, Lyons RM, Moses H, Rifkin DB. Characterization of the activation of latent TGF-beta by cocultures of endothelial cells and pericytes in smooth muscle cells: a self-regulating system. J Cell Biol 1990; 111: 757
    CrossrefPubMedGoogle Scholar
  • 13 Antonelli-Orlidge A, Saunders KB, Smith SR, D'Amore PA. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci USA 1989; 86: 4544
    CrossrefPubMedGoogle Scholar
  • 14 Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 1988; 106: 1659-1665
    CrossrefPubMedGoogle Scholar
  • 15 Odkeon L, Blasi F, Rifkin DB. A requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-β to TGF-β. Submitted for publication.
    PubMedGoogle Scholar
  • 16 Kojima S, Harpel PC, Rifkin DB. Lipoprotein(a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol 1991; 113: 1439-1445
    CrossrefPubMedGoogle Scholar
  • 17 Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent man-nose 6-phosphate insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 1991; 88: 580
    CrossrefPubMedGoogle Scholar
  • 18 Flaumenhaft R, Abe M, Sato Y, Miyazono K, Harpel JG, Heldin CH, Rifkin DB. Role of the latent TGF-β binding protein in the activation of latent TGF-β by co-cultures of endothelial and smooth muscle cells. J Cell Biol 1993; 120: 995-1002
    CrossrefPubMedGoogle Scholar
  • 19 Kojima S, Nara K, Rifkin DB. Requirement for transglutaminase in the activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Biol. 1993 in press
    PubMedGoogle Scholar
  • 20 Bendixen E, Borth W, Harpel PC. Cross-linking of plasminogen to fibronectin by factor XIIIa and tissue transglutaminase. Blood 1991; 78: 283a
    PubMedGoogle Scholar
  • 21 Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB. Retinoic acid induces transforming growth factor-β2 in cultured keratinocytes and mouse epidermis. Cell Reg 1989; 1: 87-97
    PubMedGoogle Scholar
  • 22 Kojima S, Rifkin DB. Mechanism of retinoid-induced activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Physiol. 1993 in press
    PubMedGoogle Scholar
  • 23 Flaumenhaft R, Abe M, Mignatti P, Rifkin DB. Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity. J Cell Biol 1992; 118: 901
    CrossrefPubMedGoogle Scholar