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Thromb Haemost 1989; 61(01): 140-143
DOI: 10.1055/s-0038-1646543
Original Article
Schattauer GmbH Stuttgart

Hypercoagulable State in the Watanabe Heritable Hyperlipidemic Rabbit, an Animal Model for the Progression of Atherosclerosis

Effect of Probucol on Coagulation
Yoshitaka Mori
*   The Second Department of Internal Medicine, Faculty of Medicine, Mie University, Japan
,
Hideo Wada
*   The Second Department of Internal Medicine, Faculty of Medicine, Mie University, Japan
,
Yutaka Nagano
**   The Third Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan
,
Katsumi Deguch
*   The Second Department of Internal Medicine, Faculty of Medicine, Mie University, Japan
,
Toru Kita
**   The Third Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan
,
Shigeru Shirakawa
*   The Second Department of Internal Medicine, Faculty of Medicine, Mie University, Japan
› Author Affiliations
Further Information

Publication History

Received 18 April 1988

Accepted after revision 14 October 1988

Publication Date:
24 July 2018 (online)

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Summary

Blood coagulation in a strain of rabbits designated as Watanabe heritable hyperlipidemic (WHHL) rabbits was examined. The activities of vitamin K-dependent clotting factors, contact factors and clotting factor VIII (F VIII) and the fibrinogen level were significantly higher in WHHL rabbits than in normolipidemic rabbits (all age groups). Values for vitamin Independent clotting factor were already higher at 2 months of age. Contact factors and fibrinogen levels increased age after 5 to 8 months. F VIII increased between 5 and 8 months and then decreased. At 2 months of age, WHHL rabbits were divided into two groups. Group A was fed standard rabbit chow and group B standard rabbit chow containing 1% probucol. Probucol prevented the progression of atherosclerosis in group B in the absence of a significant reduction in plasma cholesterol level. F VIII and fibrinogen levels were statistically decreased in all rabbits at all ages in group B (P<0.05). These differences in clotting factors between the two groups were most obvious at 8 months (P<0.02).

We conclude that vitamin K-dependent clotting factors may increase with hyperlipemia and that increases in F VIII and fibrinogen may be closely related to the progression of throm- boatherosclerosis.

Key words

Factor VIII - Fibrinogen - Watanabe heritable hyperlipidemic (WHHL) rabbit - Hypercholesterolemia - Atherosclerosis - Probucol
 

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