Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1978; 39(01): 069-073
DOI: 10.1055/s-0038-1646656
DOI: 10.1055/s-0038-1646656
Original Article
Effect of Orthostatic Changes on Urokinase Excretion
Further Information
Publication History
Received 08 March 1997
Accepted 26 May 1997
Publication Date:
12 July 2018 (online)
Summary
The effects of orthostatic changes on the excretion of urokinase were studied in healthy normal volunteers. Urokinase excretion rose (average +69%) significantly (p<.005) while urine volume fell (average–59%) significantly (p <.001) after the subjects had been standing. There was no difference between men and women nor was there an apparent diurnal variation in urokinase excretion of recumbent subjects. A relationship between urokinase excretion and sympathetic nervous system activity is suggested.
- 1 Bernik MB, White WF, Oller EP, Kwaan HC. 1974; Immunologic identity of plasminogen activator in human urine, heart, blood vessels and tissue culture. Journal of Laboratory and Clinical Medicine 84: 546
- 2 Biggs R, MacFarlane RG, Pilling J. 1947; Observations on fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet I: 402
- 3 Cash JD. 1966; Effect of moderate exercise on the fibrinolytic system in normal young men and women. British Medical Journal 2: 502
- 4 Celander DR, Guest MM. 1960; The biochemistry and physiology of urokinase. American Journal of Cardiology 6: 409
- 5 Duckert F. 1968. In: Enzymes in Urine and Kidney. Dubach UC. (ed.) Williams & Wilkins, Baltimore; Maryland: 237 264
- 6 Fearnley GR, Balmforth G, Fearnley E. 1957; Evidence of a diurnal fibrinolytic rhythm. With a simple method of measuring natural fibrinolysis. Clinical Science 16: 645
- 7 Holemans R, McConnell D, Johnston JG. 1966; Urokinase levels in urine after nicotinic acid injection. Thrombosis et Diathesis Haemorrhagica 15: 192
- 8 Imanari T, Wilcox GM, Pisano JJ. 1976; Sensitive radiochemical esterolytic assay for urokinase. Clinica Chimica Acta 71: 267
- 9 Karkl NT. 1956; The urinary excretion of noradrenaline and adrenaline in different age groups, its diurnal viriation and the effect of muscular work on it. Acta Physiologica Scandinavia 36: 07 Suppl (Suppl. 132)
- 10 Kucinski CS, Fletcher AP, Sherry S. 1968; Effect of urokinase anti-serum on plasminogen activators. Demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase. Journal of Clinical Investigation 47: 1238
- 11 Macfarlane RG, Pilling J. 1947; Fibrinolytic activity of normal urine. Nature 159: 779
- 12 Rosing DR, Brakman P, Redwood DR, Goldstein RE, Beiser GD, Astrup T, Epstein SE. 1970; Blood fibrinolytic activity in man. Diurnal variation and the response to varying intensities of exercise. Circulation Research 27: 171
- 13 Smyrniotis FE, Fletcher AP, Alkjaersig N, Sherry S. 1959; Urokinase excretion in health and its alteration in certain disease states. Thrombosis et Diathesis Haemorrhagica 3: 257
- 14 Sobel GW, Mohler SR, Jones NW, Dowdy ABC, Guest MM. 1952; Urokinase: An activator of plasma profibrinolysin extracted from urine. American Journal of Physiology 171: 768
- 15 Sudin T. 1958; The effect of body posture on the urinary excretion of adrenaline and noradrenaline. Acta Medica Scandivia 161: 05 Suppl (Suppl. 336)
- 16 von Kaulla KN, Riggenbach N. 1960; Urokinase excretion in man. A method of determination and consideration of its significance. Thrombosis et Diathesis Diathermia Haemorrhagica 5: 162