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Thromb Haemost 1978; 39(01): 097-108
DOI: 10.1055/s-0038-1646660
Original Article
Schattauer GmbH Stuttgart

Purification of a Fibrinolysis Inhibitor in Serum from Post-Traumatic Patients[*]

Lars Bagge
The Department of Forensic Medicine, University of Uppsala and Department of Medical and Physiological Chemistry, Royal Veterinary College, The Biomedical Centre, Uppsala, Sweden
,
Ingemar Björk
The Department of Forensic Medicine, University of Uppsala and Department of Medical and Physiological Chemistry, Royal Veterinary College, The Biomedical Centre, Uppsala, Sweden
,
Tom Saldeen
The Department of Forensic Medicine, University of Uppsala and Department of Medical and Physiological Chemistry, Royal Veterinary College, The Biomedical Centre, Uppsala, Sweden
,
Rolf Wallin
The Department of Forensic Medicine, University of Uppsala and Department of Medical and Physiological Chemistry, Royal Veterinary College, The Biomedical Centre, Uppsala, Sweden
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Publikationsverlauf

Received 06. Januar 1977

Accepted 15. Juni 1977

Publikationsdatum:
12. Juli 2018 (online)

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Summary

A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also found in normal serum, but in a lower concentration.

* This investigation was presented at the 8th Meeting of the Swedish Society for Forensic Medicine, Stockholm, November 29th, 1975. A brief report from this meeting has earlier been published (Forensic Science 7, 83, March 1976).


 

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