Thromb Haemost 1978; 39(03): 646-656
DOI: 10.1055/s-0038-1646739
Original Article
Schattauer GmbH Stuttgart

Quantitative Estimation of Coagulation Factors in Liver Disease. The Diagnostic and Prognostic Value of Factor XIII, Factor V and Plasminogen

L Biland
1   The Department of Internal Medicine, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
F Duckert
1   The Department of Internal Medicine, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
S Prisender
1   The Department of Internal Medicine, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
D Nyman
1   The Department of Internal Medicine, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
› Author Affiliations
Further Information

Publication History

Received 21 April 1977

Accepted 19 November 1977

Publication Date:
12 July 2018 (online)

Summary

20 coagulation parameters were investigated in 144 patients with different liver diseases. The groups of acute hepatitis, chronic active hepatitis and liver cirrhosis were compared and the prognostic value of the coagulation analyses investigated. It is clear that the determination of the factor V activity is a good and easy test for detection of actual liver function. Repeated controls over several weeks revealed with a statistical significance (p <0.0005) that all patients with a factor XIII below 35& and a plasminogen below 19& will die in liver coma, if they have not died beforehand from acute gastrointestinal haemorrhage, acute infection or cardiac arrest.

Plasminogen is also lower in the group of non-survivors but the values of the two groups are overlapping and of no prognostic help in a single case. The possible causes of the diminution of factor XIII activity are discussed.

 
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