Thromb Haemost 1978; 39(03): 663-674
DOI: 10.1055/s-0038-1646741
Original Article
Schattauer GmbH Stuttgart

Acquired Inhibitors of Factor V[*]

Donald I Feinstein
Division of Hematology, Department of Medicine, University of Southern California School of Medicine and Los Angeles County-USC Medical Center, Los Angeles, California, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 28 October 1977

Accepted 31 October 1977

Publication Date:
12 July 2018 (online)

Summary

The clinical and laboratory data on the 12 patients with an acquired inhibitor to factor V have been reviewed. The degree of clinical bleeding in these patients varied from none to severe, and in most patients the inhibitor was transient. The combination of a markedly prolonged partial thromboplastin time and Quick prothrombin time and failure of normal plasma to correct these tests, in the presence of a normal thrombin and prothrombin and proconvertin time, seems to be pathognomonic for a factor V inhibitor. The inhibitors have physicochemical properties of immunoglobulins and a few have been characterized as polyclonal IgG antibodies or a mixture of IgM and IgG antibodies. The etiology and pathophysiologic mechanism of their development is unknown, but there seems to be a close relationship to major surgery. When tested with inhibitor plasma, the plasmas from 9 patients with hereditary factor V deficiency from 7 unrelated families did not contain factor V antibody-neutralizing material.

* Presented in part at a symposium on Immune Disorders of Hemostasis at the VIth Congress of the International Society on Thrombosis and Haemostasis, Philadelphia, Pennsylvania, U.S.A., June 26–July 2, 1977.


 
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