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Thromb Haemost 1978; 39(03): 695-700
DOI: 10.1055/s-0038-1646745
Original Article
Schattauer GmbH Stuttgart

Heparin Neutralizing Activity in Patients with Renal Disease on Maintenance Haemodialysis

A Aronstam
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
,
B Dennis
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
,
M J Friesen
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
,
W F Clark
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
,
A L Linton
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
,
R M Lindsay
The Renal Unit and Department of Medicine, Victoria Hospital, London, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Received 10 June 1977

Accepted 24 December 1977

Publication Date:
26 July 2018 (online)

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Summary

Heparin neutralizing activity (HNA) was increased in plasma of patients with end-stage renal disease treated by maintenance haemodialysis. It was not raised in non-dialyzed patients with chronic renal failure, nor in patients with normal renal function who had been exposed to the extracorporeal circulation of the heart-lung bypass 48–72 hr before testing. It is postulated that the trauma of extracorporeal circulation causes platelets to release HNA which is not cleared by the dialysis membranes of the artificial kidney but is by the human kidney. This may have therapeutic implications for heparin dosage schedules during haemodialysis.

 

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