Summary
Using the chromogenic substrate, Tos-Gly-Pro-Arg-pNA-HCL (Chromozym TH, Boehringer
Mannheim) plasma thrombin was estimated in six cases of envenomation by Australian
elapid snakes. All patients manifested findings chracteristic of defibrination due
to envenomation by these snakes. Fibrin-fibrinogen degradation products were grossly
elevated, as was plasma thrombin in all cases.
Following treatment with antivenene, all abnormal coagulation parameters returned
rapidly towards normal by 24 hours and plasma thrombin disappeared.
