Liquoid Induced Stasis and the Generalized Shwartzman Reaction

Summary

The composition of the occlusive material within dilated glomerular capillaries, following intravenous injections of Liquoid in blue foxes, was studied electron microscopically; it was found that it mainly consisted of a debris in which disintegrated red cells constituted the major component. Damaged platelets and necrotic endothelial remnants were other components. These observations were interpreted as a result of glomerular stasis, and it was concluded that stasis in glomerular capillaries is a basic event in the development of the renal lesions accompanying the generalized Shwartzman reaction.

• References

• 1 Bohle A, Sitte H, Miller F. 1957; Elektronenmikroskopische Untersuchungen am Glomerulum des Kaninchens beim generalisierten Shwartzman-Phänomen. Verhandlungen der Deutschen Gesellschaft fiir Pathologie 41: 326
• 2 Brain MC, Hourihane DO B. 1967; Microangiopathic haemolytic anemia: the occurrence of haemolysis in experimentally produced vascular disease. British Journal of Haematology 13: 135
• 3 Brain MC, Esterly JR, Beck EA. 1967; Intravascular haemolysis with experimentally produced vascular thrombi. British Journal of Haematology 13: 868
• 4 Kreyberg L. 1963. Stasis and Necrosis. Universitetsforlaget; Oslo:
• 5 Mckay DG. 1965. Disseminated Intravascular Coagulation. An intermediary mechanism of disease Hoeber Medical Division; New York:
• 6 Meerbach W, RÜdiger KD, Wöckel W. 1977; Tierexperimentelle Untersuchungen zum Problem der disseminierten intravaskulären Gerinnung. Experimentelle Pathologie 13: 58
• 7 Nordstoga K. 1974; Porcine salmonellosis: A counterpart to the generalized Shwartzman reaction. Origin of hyaline material precipitated in minute vessels Acta Pathologica et Microbiologica Scandinavica Section A 82: 690
• 8 Nordstoga K. 1977; a Disseminated intravascular coagulation: A pathologist’s view. Thrombosis and Haemostasis 37: 180
• 9 Nordstoga K. 1977; b Liquoid-induced arterial lesions and the generalized Shwartzman reaction. Acta Veterinaria Scandinavica 18: 515
• 10 Nordstoga K. 1977; c The sequence of events in the development of bilateral renal cortical necrosis accompanying the generalized Shwartzmann reaction. Acta Veterinaria Scandinavica 18: 522
• 11 RodrÍguez-Erdmann F, Krecke HJ, Lasch HG, Bohle A. 1960; Über die morphologis-chen und Gerinnungsanalytischen Veränderungen nach Liquoid. Ein Beitrag zur Pathogenese des Sanarelli-Shwartzman-Phänomens Zeitschrift für die Gesamte Experimentelle Medizin 134: 109
• 12 Schiefer B, Searcy G. 1975; Disseminated intravascular coagulation and consumption coagulopathy. Canadian Veterinary Journal 16: 151
• 13 Sharp AA. 1977; Diagnosis and management of disseminated intravascular coagulation. British Medical Bulletin 33: 265
• 14 Still WJ S, Scott GB D. 1966; An electron microscopic study of the endothelial changes and the nature of »fibrinoid« produced in the generalized Shwartzman reaction. Experimental and Molecular Pathology 5: 118
• 15 Urizar RE, Sherer G, Tartaglia A, Pickering RJ, Dodds WJ. 1975; Disseminated intravascular coagulation induced by Liquoid in the rat. I. Correlation of hematologic and complement abnormalities with renal lesions studied by light, fluorescence, and electron microscopy Laboratory Investigation 32: 270
• 16 Watanabe T, Tanaka K. 1977; Electron microscopic observations of the kidney in the generalized Shwartzman reaction. Virchows Archiv. Abteil A. Pathologische Anatomie 374: 183