Patterns of Incorporation of 75Se-Methionine into Fibrinogen and Other Plasma Proteins in Rabbits Stimulated by Different Test Conditions

Uri Seligsohn; Samuel I. Rapaport; Ariella Zivelin

doi:10.1055/s-0038-1647747

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(01): 076-086
DOI: 10.1055/s-0038-1647747

Original Article

Schattauer GmbH

Patterns of Incorporation of ⁷⁵Se-Methionine into Fibrinogen and Other Plasma Proteins in Rabbits Stimulated by Different Test Conditions

Authors

Uri Seligsohn^*

¹Department of Medicine, University of Southern California School of Medicine Los Angeles, California 90033
Samuel I. Rapaport

¹Department of Medicine, University of Southern California School of Medicine Los Angeles, California 90033
Ariella Zivelin

¹Department of Medicine, University of Southern California School of Medicine Los Angeles, California 90033

Abstract

Summary

Rabbits were injected with ⁷⁵Se-Methionine (⁷⁵SeM) 4-8 hr after being subjected to a variety of experimental conditions: injection of ACTH, growth hormone, glucagon, adrenalin, endotoxin, turpentine, hydrocortisone and laparotomy. All of these experimental conditions except injection of glucagon were associated with increased incorporation of ⁷⁵SeM into fibrinogen. Three patterns of incorporation of ⁷⁵SeM into plasma proteins were recognized: 1. the pituitary pattern, which was observed in animals injected with ACTH, growth hormone or endotoxin, and which was characterized by increased incorporation of ⁷⁵SeM only into fibrinogen and by a delayed incorporation of ⁷⁵SeM into α₂ and β₁ globulins; 2. the tissue injury pattern, which was characterized by a markedly increased incorporation of ⁷⁵SeM into fibrinogen and no alteration in incorporation of ⁷⁵SeM into α₂ or β₁ globulins; and 3. the pharmacologic corticosteroid pattern, which was characterized by a moderately increased incorporation of ⁷⁵SeM into fibrinogen and a strikingly increased incorporation of ⁷⁵SeM into α₂ and β₁ globulins.

Full Text

References

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